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Adaptin Ear Binding Coat Associated Protein 1 (NECAP1)

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NECAP1; NECAP endocytosis-associated protein 1

Adaptin Ear Binding Coat Associated Protein 1 (NECAP1)
CCC K428
HGNC 24539
MGI 1914852
PubMed 14555962
RGD 1306053
UniProt Q8NC96
Through a proteomic analysis of rat brain clathrin-coated vesicles, Ritter et al. (2003) identified Necap1. The deduced protein contains 275 amino acids. Western blot analysis detected Necap1 expression primarily in brain.
Ritter et al. (2003) identified a motif (WVQF) in the rat Necap1 protein that bound directly to the globular ear domain of the alpha-adaptin subunit (AP2A1) of the adaptor protein-2 (AP-2) complex. Mutations in this sequence blocked clathrin-mediated endocytosis.
Hartz (2007) mapped the NECAP1 gene to chromosome 12p13.31 based on an alignment of the NECAP1 sequence with the genomic sequence (build 36.1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptin Ear Binding Coat Associated Protein 1 (NECAP1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  5. "NECAP1 loss of function leads to a severe infantile epileptic encephalopathy."J. Med. Genet. 51:224-228(2014) [PubMed] [Europe PMC] [Abstract]