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CUGBP Elav Like Family, Member 1 (CELF1)

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CUGBP1; CUG-BP; hNab50; BRUNOL2; NAB50; CUGBP; NAPOR; EDEN-BP; CUG Triplet Repeat,RNA-Binding Protein 1; Embryo Deadenylation Element Binding Protein

CUGBP Elav Like Family, Member 1 (CELF1)
CCC K417
HGNC 2549
MGI 1342295
PubMed 23324604
RGD 1307721
UniProt Q92879
The CUGBP1binding only to the RNA repeat (CUG)8 was inhibited by nonlabeled (CUG)8 but not by nonlabeled single- or double-stranded CTG repeats. Furthermore, the protein, designated CUG-binding protein (CUGBP) by the authors, exhibited no binding to an RNA oligonucleotide of triplet repeats of the same length but having a different sequence, CGG. The CUG-binding protein was localized to the cytoplasm, whereas double-stranded DNA binding proteins were localized to the nuclear extract.
The deduced protein contains 2 N-terminal RNA recognition motifs (RRMs), a long linker region, and a C-terminal RRM. BRUNOL2 and BRUNOL3 (CUGBP2) share 80% amino acid identity overall and more than 92% identity in their RRMs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a Monoclonal Antibody to CUGBP Elav Like Family, Member 1 (CELF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUGBP Elav Like Family, Member 1 (CELF1) Polyclonal Antibody Customized Service Offer
Assay Kits SEK417Hu ELISA Kit for CUGBP Elav Like Family, Member 1 (CELF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUGBP Elav Like Family, Member 1 (CELF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUGBP Elav Like Family, Member 1 (CELF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUGBP Elav Like Family, Member 1 (CELF1) Polyclonal Antibody Customized Service Offer
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n/a ELISA Kit for CUGBP Elav Like Family, Member 1 (CELF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CUGBP Elav Like Family, Member 1 (CELF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CUGBP Elav Like Family, Member 1 (CELF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CUGBP Elav Like Family, Member 1 (CELF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CUGBP Elav Like Family, Member 1 (CELF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CUGBP Elav Like Family, Member 1 (CELF1) ELISA Kit Customized Service Offer
  1. "Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy."Nucleic Acids Res. 24:4407-4414(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator."J. Biol. Chem. 275:28583-28592(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells."J. Biochem. 130:581-587(2001) [PubMed] [Europe PMC] [Abstract]
  4. "c-Jun ARE targets mRNA deadenylation by an EDEN-BP (embryo deadenylation element-binding protein)-dependent pathway."J. Biol. Chem. 277:3232-3235(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms."Nucleic Acids Res. 27:4517-4525(1999) [PubMed] [Europe PMC] [Abstract]
  9. "RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1."J. Biol. Chem. 276:7820-7826(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing."Mol. Cell. Biol. 21:1285-1296(2001) [PubMed] [Europe PMC] [Abstract]
  11. "A functional deadenylation assay identifies human CUG-BP as a deadenylation factor."Biol. Cell 95:107-113(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein."RNA 9:443-456(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate."EMBO J. 23:406-417(2004) [PubMed] [Europe PMC] [Abstract]
  14. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing."EMBO J. 25:4271-4283(2006) [PubMed] [Europe PMC] [Abstract]
  16. "ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I."J. Neurosci. Res. 84:852-859(2006) [PubMed] [Europe PMC] [Abstract]
  17. "CUG-BP binds to RNA substrates and recruits PARN deadenylase."RNA 12:1084-1091(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of RNA-binding domain 3 in CUG triplet repeat RNA-binding protein 1."Submitted (NOV-2005) to the PDB data bank
  22. "Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1."Structure 18:1364-1377(2010) [PubMed] [Europe PMC] [Abstract]