Non Metastatic Cells 4, Protein NM23A Expressed In (NME4)

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NM23H4; nm23-H4; NDK; NDPKD; NM23D; Nucleoside diphosphate kinase, mitochondrial; Nucleoside diphosphate kinase D

Non Metastatic Cells 4, Protein NM23A Expressed In (NME4)
The full-length cDNA sequence predicts a 187-amino acid protein possessing the region homologous to NDP kinases with all residues crucial for nucleotide binding and catalysis, strongly suggesting that the new gene possesses NDP kinase activity. It shares 56, 55, and 60% identity with NME1, NME2, and NME3, respectively.
Compared with these other proteins, NME4 contains an additional N-terminal region that is rich in positively charged residues and could indicate routing to mitochondria. The corresponding 1.2-kb mRNA was widely distributed and expressed in tissue-dependent manner, being found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK244Hu01 Recombinant Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK244Hu01 Polyclonal Antibody to Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK244Mu01 Recombinant Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK244Mu01 Polyclonal Antibody to Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Metastatic Cells 4, Protein NM23A Expressed In (NME4) ELISA Kit Customized Service Offer
  1. "nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13."Hum. Genet. 99:550-557(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes."Biophys. J. 92:126-137(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration."J. Biol. Chem. 283:26198-26207(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch."J. Biol. Chem. 288:111-121(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling."Science 344:1510-1515(2014) [PubMed] [Europe PMC] [Abstract]
  9. "The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase."J. Biol. Chem. 275:14264-14272(2000) [PubMed] [Europe PMC] [Abstract]