≡

Non Metastatic Cells 1, Protein NM23A Expressed In (NME1)

[Edit]

AWD; GAAD; NDPKA; NM23-H1; Nucleoside diphosphate kinase A; Granzyme A-activated DNase; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein

Non Metastatic Cells 1, Protein NM23A Expressed In (NME1)
CCC J817
HGNC 7849
MGI 97355
PubMed 23856325
RGD 70497
UniProt P15531
Wiki NME1
NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.
Human NM23 protein has sequence homology over the entire translated region with a developmentally related protein in Drosophila encoded by the 'abnormal wing discs' (awd) gene. Mutations in awd cause abnormal tissue morphology and necrosis and widespread aberrant differentiation in Drosophila, analogous to the changes in malignant progression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ817Hu01 Recombinant Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ817Hu01 Polyclonal Antibody to Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ817Mu01 Recombinant Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ817Mu01 Polyclonal Antibody to Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ817Ra01 Recombinant Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ817Ra21 Monoclonal Antibody to Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) WB; IHC; ICC; IP.
PAJ817Ra01 Polyclonal Antibody to Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) WB; IHC; ICC; IP.
Assay Kits SEJ817Ra ELISA Kit for Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development."Nature 342:177-180(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme."J. Biol. Chem. 266:8784-8789(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Mutation in the nm23 gene is associated with metastasis in colorectal cancer."Cancer Res. 53:717-720(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1."Hum. Genet. 93:63-66(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and characterization of a novel human NM23-H1B gene, a different transcript of NM23-H1."J. Hum. Genet. 48:96-100(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification."J. Clin. Invest. 88:341-345(1991) [PubMed] [Europe PMC] [Abstract]
  10. , Submitted (DEC-2008) to UniProtKB
  11. "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells."J. Biol. Chem. 271:25107-25116(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display."Genomics 61:5-14(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."Cell 112:659-672(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV."Genomics 87:483-489(2006) [PubMed] [Europe PMC] [Abstract]
  15. "The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death."Mol. Cell 23:133-142(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility."Oncogene 27:1853-1864(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor."Proteins 46:340-342(2002) [PubMed] [Europe PMC] [Abstract]
  22. "Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases."J. Mol. Biol. 332:915-926(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Nm23-H1 mutation in neuroblastoma."Nature 370:335-336(1994) [PubMed] [Europe PMC] [Abstract]