≡

LIM And SH3 Protein 1 (LASP1)

[Edit]

MLN50; Metastatic lymph node gene 50 protein

LIM And SH3 Protein 1 (LASP1)
CCC J738
HGNC 6513
MGI 109656
PubMed 19531578
RGD 68408
UniProt Q14847
Wiki LASP1
LASP1 encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.
In breast cancer cell lines, overexpression of the 4 kb MLN50 mRNA was correlated with amplification of the gene and with amplification and overexpression of ERBB2, which maps to the same region. The authors suggested that the 2 genes belong to the same amplicon. Amplification of chromosomal region 17q11-q21 is one of the most common events occurring in human breast cancers.Northern blot analysis revealed that LASP1 mRNA was expressed at a basal level in all normal tissues examined and overexpressed in 8% of primary breast cancers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ738Hu01 Recombinant LIM And SH3 Protein 1 (LASP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ738Hu21 Monoclonal Antibody to LIM And SH3 Protein 1 (LASP1) WB; IHC; ICC; IP.
PAJ738Hu01 Polyclonal Antibody to LIM And SH3 Protein 1 (LASP1) WB; IHC; ICC; IP.
Assay Kits SEJ738Hu ELISA Kit for LIM And SH3 Protein 1 (LASP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And SH3 Protein 1 (LASP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And SH3 Protein 1 (LASP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And SH3 Protein 1 (LASP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And SH3 Protein 1 (LASP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And SH3 Protein 1 (LASP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LIM And SH3 Protein 1 (LASP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LIM And SH3 Protein 1 (LASP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LIM And SH3 Protein 1 (LASP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LIM And SH3 Protein 1 (LASP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LIM And SH3 Protein 1 (LASP1) ELISA Kit Customized Service Offer
  1. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains."FEBS Lett. 373:245-249(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension."J. Biol. Chem. 284:30498-30507(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]