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Artemin is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease.
Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ596Hu01 | Recombinant Artemin (ARTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ596Hu01 | Polyclonal Antibody to Artemin (ARTN) | WB; IHC; ICC; IP. |
| MAJ596Hu21 | Monoclonal Antibody to Artemin (ARTN) | WB; IHC; ICC; IP. | |
| Assay Kits | SEJ596Hu | ELISA Kit for Artemin (ARTN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ596Mu01 | Recombinant Artemin (ARTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ596Mu01 | Polyclonal Antibody to Artemin (ARTN) | WB,IHC |
| LAJ596Mu71 | Biotin-Linked Polyclonal Antibody to Artemin (ARTN) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Artemin (ARTN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Artemin (ARTN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ596Ra01 | Recombinant Artemin (ARTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ596Ra01 | Polyclonal Antibody to Artemin (ARTN) | WB |
| LAJ596Ra71 | Biotin-Linked Polyclonal Antibody to Artemin (ARTN) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Artemin (ARTN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Artemin (ARTN) | ELISA Kit Customized Service Offer |
- "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex."Neuron 21:1291-1302(1998) [PubMed] [Europe PMC] [Abstract]
- "Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants."Eur. J. Biochem. 266:892-902(1999) [PubMed] [Europe PMC] [Abstract]
- "In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin."Mol. Cell. Neurosci. 15:199-214(2000) [PubMed] [Europe PMC] [Abstract]
- ErratumMol. Cell. Neurosci. 18:332-333(2001)
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors."Structure 14:1083-1092(2006) [PubMed] [Europe PMC] [Abstract]