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Destrin (DSTN)

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ADF; ACTDP; Actin Depolymerizing Factor; Actin Binding Protein

Destrin (DSTN)
CCC J225
HGNC 15750
MGI 1929270
PubMed 8674111
RGD 1304558
UniProt P60981
Wiki Destrin
Destrin belongs to the actin-binding proteins ADF/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.
In a variety of eukaryotes, destrin regulates actin in the cytoskeleton. Destrin binds actin and is thought to connect it as gelsolin segment-1 does. Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever actin filaments. At a pH of 7.3 or higher it can sever the filaments but a lower pH the ability for it to do so is limited.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ225Hu01 Recombinant Destrin (DSTN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ225Hu01 Polyclonal Antibody to Destrin (DSTN) WB; IHC; ICC; IP.
MAJ225Hu21 Monoclonal Antibody to Destrin (DSTN) WB; IHC; ICC; IP.
Assay Kits SEJ225Hu ELISA Kit for Destrin (DSTN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Destrin (DSTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Destrin (DSTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Destrin (DSTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Destrin (DSTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Destrin (DSTN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Destrin (DSTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Destrin (DSTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Destrin (DSTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Destrin (DSTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Destrin (DSTN) ELISA Kit Customized Service Offer
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