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E2F Transcription Factor 1 (E2F1)

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RBBP3; RBP3; RBAP-1; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; pRB-binding protein E2F-1

E2F Transcription Factor 1 (E2F1)
CCC J181
HGNC 3113
MGI 101941
PubMed 23966291
RGD 728892
UniProt Q01094
Wiki E2F1
E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ181Hu01 Recombinant E2F Transcription Factor 1 (E2F1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ181Hu21 Monoclonal Antibody to E2F Transcription Factor 1 (E2F1) WB; IHC; ICC; IP.
PAJ181Hu01 Polyclonal Antibody to E2F Transcription Factor 1 (E2F1) WB; IHC; ICC; IP.
Assay Kits SEJ181Hu ELISA Kit for E2F Transcription Factor 1 (E2F1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 1 (E2F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 1 (E2F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 1 (E2F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 1 (E2F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 1 (E2F1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 1 (E2F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 1 (E2F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 1 (E2F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 1 (E2F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 1 (E2F1) ELISA Kit Customized Service Offer
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  8. "Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein."Mol. Cell. Biol. 13:6501-6508(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase."Cell 78:161-172(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Differential regulation of E2F transactivation by cyclin/cdk2 complexes."Genes Dev. 8:1772-1786(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation."Mol. Cell. Biol. 14:8420-8431(1994) [PubMed] [Europe PMC] [Abstract]
  12. "P53 and E2F-1 cooperate to mediate apoptosis."Proc. Natl. Acad. Sci. U.S.A. 91:3602-3606(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription."J. Virol. 69:7759-7767(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphorylation of E2F-1 by cyclin A-cdk2."Oncogene 10:229-236(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Specific regulation of E2F family members by cyclin-dependent kinases."Mol. Cell. Biol. 17:3867-3875(1997) [PubMed] [Europe PMC] [Abstract]
  16. "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer."Oncogene 17:853-865(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of E2F1 activity by acetylation."EMBO J. 19:662-671(2000) [PubMed] [Europe PMC] [Abstract]
  18. "E2F transcriptional activation requires TRRAP and GCN5 cofactors."J. Biol. Chem. 276:32627-32634(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of E2F1 by BRCT domain-containing protein TopBP1."Mol. Cell. Biol. 23:3287-3304(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Chk2 activates E2F-1 in response to DNA damage."Nat. Cell Biol. 5:401-409(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release."Cell 123:1093-1106(2005) [PubMed] [Europe PMC] [Abstract]
  22. "EAPP, a novel E2F binding protein that modulates E2F-dependent transcription."Mol. Biol. Cell 16:2181-2190(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of E2F1 function by the nuclear corepressor KAP1."J. Biol. Chem. 282:29902-29909(2007) [PubMed] [Europe PMC] [Abstract]
  25. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes."Mol. Cell. Biol. 30:2293-2304(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription."J. Biol. Chem. 286:26406-26417(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A."Biochemistry 41:15625-15634(2002) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation."Proc. Natl. Acad. Sci. U.S.A. 100:2363-2368(2003) [PubMed] [Europe PMC] [Abstract]