Testicular Endothelial Cells (TEC)

Testicular Endothelial Cells (TEC) migrate in the developing embryo from the mesonephros to form the testis vasculature during the process of testis cord formation. The migrating endothelial cells are also essential because they initiate cord formation by creating partitions for the sertoli and germ cells. Studies show that disrupting testis vascular development blocks testis cord formation and thereby prevents proper structural development of the testis. In addition, studies suggest that testicular endothelial cells have similar properties to brain endothelial cells and contribute to the establishment of the blood-testis barrier (BTB). Cultured testicular endothelial cells can be used to study vascular defects in testicular development and provide a new perspective for the treatment of male reproductive diseases.