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Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1)

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GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D

Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1)
CCC H975
HGNC 4459
MGI 106604
PubMed 11072085
RGD 631371
UniProt P80108
Wiki GPLD1
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
The deduced amino acid sequence contains 4 regions of internal homology that are similar to the metal ion binding domains of integrin alpha subunits. Bovine PIGPLD does not exhibit phosphatidylcholine-specific PLD activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH975Hu01 Recombinant Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH975Hu01 Polyclonal Antibody to Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) WB; IHC; ICC; IP.
MAH975Hu21 Monoclonal Antibody to Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) WB; IHC; ICC; IP.
Assay Kits SEH975Hu ELISA Kit for Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1) ELISA Kit Customized Service Offer
  1. "Isolation and expression of two human glycosylphosphatidylinositol phospholipase D (GPI-PLD) cDNAs."FASEB J. 6:A1922-A1922(1992)
  2. "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene."Biochim. Biophys. Acta 1494:189-194(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D."Hunan Yi Ke Da Xue Xue Bao 26:96-97(2001)
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins."Eur. J. Biochem. 206:747-757(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]