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Zinc Finger Protein, Y-Linked (ZFY)

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Zinc Finger Protein, Y-Linked (ZFY)
CCC H938
HGNC 12870
PubMed 2497060
UniProt P08048
Wiki ZFY
ZFY encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.
The encoded protein was thought to bind to nucleic acids in a sequence-specific manner and to regulate transcription. Models of sex determination must accommodate the finding of a related locus on the X chromosome. The presence of similar sequences in birds suggested a possible role not only in the XX/XY sex determination system of mammals, but also in the ZZ/ZW system of birds. Mapping studies by hybridization to DNA from somatic cell hybrids containing various fragments of the X chromosome suggested that the sequence on the X chromosome maps to region Xp22.3-p21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Protein, Y-Linked (ZFY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Protein, Y-Linked (ZFY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Protein, Y-Linked (ZFY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Protein, Y-Linked (ZFY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Protein, Y-Linked (ZFY) ELISA Kit Customized Service Offer
  1. "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues."Am. J. Hum. Genet. 45:942-952(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Comparison of human ZFY and ZFX transcripts."Proc. Natl. Acad. Sci. U.S.A. 87:1681-1685(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans."Mol. Biol. Evol. 17:804-812(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The sex-determining region of the human Y chromosome encodes a finger protein."Cell 51:1091-1104(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY."Nucleic Acids Res. 19:2579-2586(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9."Nucleic Acids Res. 17:2987-2999(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of the DNA binding activity of the ZFY zinc finger domain."Biochemistry 49:679-686(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for 'jumping-linker' DNA recognition."Biochemistry 30:3371-3386(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition."Biochemistry 30:7063-7072(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice."Protein Sci. 13:3115-3126(2004) [PubMed] [Europe PMC] [Abstract]