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Leiomodin 2 (LMOD2)

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C-LMOD; Cardiac Leiomodin

Leiomodin 2 (LMOD2)
CCC H727
HGNC 6648
PubMed 20736303
UniProt Q6P5Q4
By searching EST databases for sequences similar to TMOD, Conley et al. (2001) cloned LMOD2, which they designated CLMOD. The deduced 547-amino acid protein contains a long C-terminal polyproline sequence.
LMOD2 shares 89% identity with the mouse Lmod2 protein. Northern blot analysis detected a 2.7-kb transcript expressed exclusively in heart and skeletal muscle. RNA dot blot analysis showed expression only in fetal and adult heart and adult skeletal muscle.
Conley et al. (2001) determined that the LMOD2 gene contains 3 exons and spans about 10 kb. Intron 1 spans more than 5 kb. By genomic sequence analysis, Conley et al. (2001) mapped the LMOD2 gene to chromosome 7q31-q32.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leiomodin 2 (LMOD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leiomodin 2 (LMOD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leiomodin 2 (LMOD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leiomodin 2 (LMOD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leiomodin 2 (LMOD2) ELISA Kit Customized Service Offer
  1. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Leiomodins: larger members of the tropomodulin (Tmod) gene family."Genomics 73:127-139(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy." J. Clin. Invest. 124:4693-4708(2014) [PubMed] [Europe PMC] [Abstract]