Latexin (LXN)
[Edit]ECI; TCI; MUM; Endogenous carboxypeptidase inhibitor; Tissue carboxypeptidase inhibitor
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Latexin is a specific inhibitor of zinc-dependent metallocarboxypeptidases. The deduced 222-amino acid protein is an elongated molecule with N- and C-terminal domains that each consist of an alpha helix enveloped by a curved beta sheet. The 2 domains are separated by a connecting segment.Lxn was less potent against other mammalian carboxypeptidases, and it did not inhibit other metallopeptidases or serine proteases.
It also showed low specificity, inhibiting several metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold. The inhibition constant was within the nanomolar range for these substrates. LXN did not inhibit enzymes of other carboxypeptidase classes.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH709Hu01 | Recombinant Latexin (LXN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH709Hu01 | Polyclonal Antibody to Latexin (LXN) | WB; IHC; ICC; IP. |
| LAH709Hu71 | Biotin-Linked Polyclonal Antibody to Latexin (LXN) | WB; IHC; ICC. | |
| LAH709Hu81 | FITC-Linked Polyclonal Antibody to Latexin (LXN) | WB; IHC; ICC; IF. | |
| Assay Kits | n/a | CLIA Kit for Latexin (LXN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Latexin (LXN) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH709Mu01 | Recombinant Latexin (LXN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH709Mu01 | Polyclonal Antibody to Latexin (LXN) | WB; IHC; ICC; IP. |
| LAH709Mu71 | Biotin-Linked Polyclonal Antibody to Latexin (LXN) | WB; IHC; ICC. | |
| Assay Kits | SEH709Mu | ELISA Kit for Latexin (LXN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPH709Ra01 | Recombinant Latexin (LXN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAH709Ra01 | Polyclonal Antibody to Latexin (LXN) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Latexin (LXN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Latexin (LXN) | ELISA Kit Customized Service Offer |
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- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin."Proc. Natl. Acad. Sci. U.S.A. 102:3978-3983(2005) [PubMed] [Europe PMC] [Abstract]