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Periplakin (PPL)

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190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein

Periplakin (PPL)
CCC H334
HGNC 9273
MGI 1194898
PubMed 9412476
RGD 1305511
UniProt O60437
Wiki Periplakin
Periplakin is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.The deduced 1,666-amino acid protein has a calculated molecular mass of about 205 kD. PPL shares extensive sequence homology with other proteins of the plakin family, with highest identities found in the N- and C-terminal domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH334Hu01 Recombinant Periplakin (PPL) Positive Control; Immunogen; SDS-PAGE; WB.
RPH334Hu02 Recombinant Periplakin (PPL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH334Hu01 Polyclonal Antibody to Periplakin (PPL) WB; IHC; ICC; IP.
PAH334Hu02 Polyclonal Antibody to Periplakin (PPL) WB; IHC; ICC; IP.
Assay Kits SEH334Hu ELISA Kit for Periplakin (PPL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH334Mu01 Recombinant Periplakin (PPL) Positive Control; Immunogen; SDS-PAGE; WB.
RPH334Mu02 Recombinant Periplakin (PPL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH334Mu01 Polyclonal Antibody to Periplakin (PPL) WB; IHC; ICC; IP.
PAH334Mu02 Polyclonal Antibody to Periplakin (PPL) WB; IHC; ICC; IP.
Assay Kits SEH334Mu ELISA Kit for Periplakin (PPL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Periplakin (PPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Periplakin (PPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Periplakin (PPL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Periplakin (PPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Periplakin (PPL) ELISA Kit Customized Service Offer
  1. "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin."J. Cell Biol. 139:1835-1849(1997) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes."Genomics 48:242-247(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Human periplakin: genomic organization in a clonally unstable region of chromosome 16p with an abundance of repetitive sequence elements."Genomics 56:160-168(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Binding of protein kinase B to the plakin family member periplakin."J. Cell Sci. 115:3957-3966(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity."Proc. Natl. Acad. Sci. U.S.A. 101:10392-10397(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]