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Sorcin (SRI)

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SCN; CP-22; V19; 22 kDa protein

Sorcin (SRI)
CCC H133
HGNC 11292
MGI 98419
PubMed 2901906
UniProt P30626
Wiki SRI
The 22-kD sorcin protein was overexpressed in HOB1/VCR-1.0 cells, a multidrug-resistant human B immunoblastic lymphoma cell line. By PCR with primers based on the sequence of hamster sorcin, the authors recovered a partial human sorcin cDNA. Using the partial cDNA to screen a HOB1/VCR-1.0 library, they isolated cDNAs corresponding to the entire sorcin coding region. The predicted 198-amino acid human protein shares 95% sequence identity with hamster sorcin.
Human sorcin contains 4 EF-hand calcium-binding motifs. Purified protein bound calcium in vitro. Southern and Northern blot analysis revealed that the sorcin gene is amplified and overexpressed in HOB1/VCR-1.0 cells. No expression was detected in parental HOB1 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH133Hu01 Recombinant Sorcin (SRI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH133Hu01 Polyclonal Antibody to Sorcin (SRI) WB; IHC; ICC; IP.
MAH133Hu21 Monoclonal Antibody to Sorcin (SRI) WB; IHC; ICC; IP.
Assay Kits SEH133Hu ELISA Kit for Sorcin (SRI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sorcin (SRI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sorcin (SRI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sorcin (SRI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sorcin (SRI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sorcin (SRI) ELISA Kit Customized Service Offer
  1. "Isolation and molecular cloning of human sorcin a calcium-binding protein in vincristine-resistant HOB1 lymphoma cells."Biochim. Biophys. Acta 1260:285-293(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Purification, cDNA cloning, and expression of human sorcin in vincristine-resistant HOB1 lymphoma cell lines."Arch. Biochem. Biophys. 325:217-226(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Transcriptome analysis of human gastric cancer."Mamm. Genome 16:942-954(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]