Synaptotagmin Like Protein 2 (SYTL2)

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CHR11SYT; SGA72M; SLP2; Exophilin-4; Breast Cancer-Associated Antigen SGA-72M

Synaptotagmin Like Protein 2 (SYTL2)
SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.
The deduced 913-amino acid protein shares significant similarity with electric ray synaptotagmin . RT-PCR detected SYTL2 in all adult and fetal tissues examined, with highest expression in kidney and brain and in most specific brain regions examined. Very low expression was found in pancreas and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH069Hu01 Recombinant Synaptotagmin Like Protein 2 (SYTL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH069Hu21 Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
PAH069Hu01 Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) WB; IHC; ICC; IP.
Assay Kits SEH069Hu ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptotagmin Like Protein 2 (SYTL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptotagmin Like Protein 2 (SYTL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptotagmin Like Protein 2 (SYTL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptotagmin Like Protein 2 (SYTL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptotagmin Like Protein 2 (SYTL2) ELISA Kit Customized Service Offer
  1. "A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates in cytotoxic granule secretion."Blood 112:5052-5062(2008) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain."Mol. Biol. Cell 18:688-696(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse."Traffic 9:446-457(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Elucidation of Rab27 recruitment by its effectors: structure of Rab27a bound to Exophilin4/Slp2-a."Structure 16:1468-1477(2008) [PubMed] [Europe PMC] [Abstract]