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Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1)

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ARA55; HIC-5; HIC5; TSC-5; Androgen receptor coactivator 55 kDa protein; Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein

Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1)
CCC H039
HGNC 11767
MGI 102784
PubMed 21984848
RGD 620173
UniProt O43294
Wiki TGFB1I1
Like the mouse Hic5 protein, the deduced human protein contains 444 amino acids with 4 LIM domains. They share 97% sequence identity in the double zinc finger LIM domains and 84.3% in the N-terminal domains. Both show sequence homology with the paxillin protein. Hic5 and Pparg colocalized to the villus epithelium of mouse small intestine, and their expression during embryonic gut development correlated with the transition from endoderm to specialized epithelium. Overexpression of HIC5 in colon cancer cells enhanced PPARG-mediated induction of several gut epithelial differentiation and maturation markers. Overexpression of HIC5 during mouse preadipocyte differentiation inhibited adipogenesis while inducing inappropriate expression of several mRNAs characteristic of gut epithelium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH039Hu01 Recombinant Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH039Hu01 Polyclonal Antibody to Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH039Ra01 Recombinant Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH039Ra01 Polyclonal Antibody to Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transforming Growth Factor Beta 1 Induced Transcript 1 (TGFb1I1) ELISA Kit Customized Service Offer
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  8. "Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn."FEBS Lett. 474:179-183(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular cloning of human Hic-5, a potential regulator involved in signal transduction and cellular senescence."Mol. Carcinog. 27:177-183(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2."Biochem. J. 355:691-697(2001) [PubMed] [Europe PMC] [Abstract]
  11. "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk."Blood 97:2633-2639(2001) [PubMed] [Europe PMC] [Abstract]
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  14. "Different expression of androgen receptor coactivators in human prostate."Urology 58:289-294(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Transcriptional activation of the c-fos gene by a LIM protein, Hic-5."Biochem. Biophys. Res. Commun. 299:360-365(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Hic-5 interacts with GIT1 with a different binding mode from paxillin."J. Biochem. 132:279-289(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator."J. Biol. Chem. 277:15426-15431(2002) [PubMed] [Europe PMC] [Abstract]
  18. "The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter."J. Neurosci. 22:7045-7054(2002) [PubMed] [Europe PMC] [Abstract]
  19. "The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs."J. Biol. Chem. 278:23691-23698(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Expression of the LIM proteins paxillin and Hic-5 in human tissues."J. Histochem. Cytochem. 51:513-521(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal."Mol. Biol. Cell 14:1158-1171(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells."Proc. Natl. Acad. Sci. U.S.A. 100:5124-5129(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines."Prostate 56:192-200(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation."J. Cell. Biochem. 92:810-819(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Hic-5 regulates an epithelial program mediated by PPARgamma."Genes Dev. 19:362-375(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling."J. Biol. Chem. 280:5154-5162(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Subcellular targeting of oxidants during endothelial cell migration."J. Cell Biol. 171:893-904(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells."Cancer Res. 66:7326-7333(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  30. "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5."J. Biol. Chem. 281:16821-16832(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter."J. Biol. Chem. 281:24769-24780(2006) [PubMed] [Europe PMC] [Abstract]
  32. "Mechanism of action of Hic-5/androgen receptor activator 55, a LIM domain-containing nuclear receptor coactivator."Mol. Endocrinol. 20:56-64(2006) [PubMed] [Europe PMC] [Abstract]
  33. "Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5."Neuroendocrinology 84:285-300(2006) [PubMed] [Europe PMC] [Abstract]
  34. "Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets."Biochem. J. 403:275-281(2007) [PubMed] [Europe PMC] [Abstract]
  35. "Hic-5/ARA55 a prostate stroma-specific AR coactivator."Steroids 72:218-220(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  38. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  39. "Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5."PLoS ONE 7:E49428-E49428(2012) [PubMed] [Europe PMC] [Abstract]
  40. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  41. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]