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Transcobalamin I (TCN1)

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TCI; TC1; Haptocorin; Haptocorrin; Vitamin B12 Binding Protein,R Binder Family

Transcobalamin I (TCN1)
CCC G794
HGNC 11652
PubMed 1463480
UniProt P20061
Wiki Haptocorrin
There are 3 types of human vitamin B12-binding proteins: gastric intrinsic factor (GIF), also known as transcobalamin III; plasma transcobalamin II (TCN2); and transcobalamin I (TCN1), an R binder protein. R binder proteins are a class of immunologically identical but electrophoretically distinct glycoproteins found in many secretions, such as saliva, gastric juice, tears, milk and leukocytes, and differ only in their carbohydrate content; 'R' denotes 'rapid,' referring to electrophoretic mobility. Transcobalamin I is also found in neutrophils, where it is restricted to the secondary granules.
The deduced 433-residue protein showed extensive areas of homology with rat gastric intrinsic factor, which implicated regions potentially important for vitamin B12 binding.Comparison of the genomic structures of TCN1 and GIF suggested that the 2 genes arose by a gene duplication.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG794Hu01 Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG794Hu02 Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG794Hu03 Recombinant Transcobalamin I (TCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG794Hu01 Polyclonal Antibody to Transcobalamin I (TCN1) WB
MAG794Hu21 Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
MAG794Hu22 Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
MAG794Hu23 Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
MAG794Hu24 Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
MAG794Hu25 Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
MAG794Hu27 Monoclonal Antibody to Transcobalamin I (TCN1) WB; IHC; ICC; IP.
Assay Kits SEG794Hu ELISA Kit for Transcobalamin I (TCN1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  6. "Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin."J. Biol. Chem. 288:25466-25476(2013) [PubMed] [Europe PMC] [Abstract]