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Arylsulfatase B (ARSB)

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ASB; G4S; N-acetylgalactosamine-4-sulfatase

Arylsulfatase B (ARSB)
CCC G610
HGNC 714
MGI 88075
PubMed 22428001
RGD 2158
UniProt P15848
Wiki ARSB
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
The deduced 533-residue protein has 6 potential N-glycosylation sites. Comparison of the predicted amino acid sequences of arylsulfatases A (ARSA), B, and C (ARSC) demonstrated regions of identity, particularly in their N termini.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG610Hu01 Recombinant Arylsulfatase B (ARSB) Positive Control; Immunogen; SDS-PAGE; WB.
APG610Hu01 Active Arylsulfatase B (ARSB) Cell culture; Activity Assays.
Antibodies PAG610Hu01 Polyclonal Antibody to Arylsulfatase B (ARSB) WB; IHC; ICC; IP.
MAG610Hu21 Monoclonal Antibody to Arylsulfatase B (ARSB) WB; IHC; ICC; IP.
Assay Kits SEG610Hu ELISA Kit for Arylsulfatase B (ARSB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arylsulfatase B (ARSB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arylsulfatase B (ARSB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arylsulfatase B (ARSB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arylsulfatase B (ARSB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arylsulfatase B (ARSB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arylsulfatase B (ARSB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arylsulfatase B (ARSB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arylsulfatase B (ARSB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arylsulfatase B (ARSB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arylsulfatase B (ARSB) ELISA Kit Customized Service Offer
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  2. "Human arylsulfatase B: MOPAC cloning, nucleotide sequence of a full-length cDNA, and regions of amino acid identity with arylsulfatases A and C."Genomics 6:149-158(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human arylsulfatase B gene."Biol. Chem. Hoppe-Seyler 374:327-335(1993) [PubMed] [Europe PMC] [Abstract]
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  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "Components and proteolytic processing sites of arylsulfatase B from human placenta."Biochim. Biophys. Acta 1159:243-247(1992) [PubMed] [Europe PMC] [Abstract]
  9. "A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency."Cell 82:271-278(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular and functional analysis of SUMF1 mutations in multiple sulfatase deficiency."Hum. Mutat. 23:576-581(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation."Clin. Exp. Metastasis 26:535-545(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Structure of a human lysosomal sulfatase."Structure 5:277-289(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). An intermediate clinical phenotype caused by substitution of valine for glycine at position 137 of arylsulfatase B."J. Biol. Chem. 266:21386-21391(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Mucopolysaccharidosis type VI: identification of three mutations in the arylsulfatase B gene of patients with the severe and mild phenotypes provides molecular evidence for genetic heterogeneity."Am. J. Hum. Genet. 50:795-800(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes."Am. J. Hum. Genet. 54:454-463(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Four novel mutant alleles of the arylsulfatase B gene in two patients with intermediate form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)."Hum. Genet. 93:259-264(1994) [PubMed] [Europe PMC] [Abstract]
  18. "N-acetylgalactosamine-4-sulfatase: identification of four new mutations within the conserved sulfatase region causing mucopolysaccharidosis type VI."Biochim. Biophys. Acta 1272:129-132(1995) [PubMed] [Europe PMC] [Abstract]
  19. "Identification, expression, and biochemical characterization of N-acetylgalactosamine-4-sulfatase mutations and relationship with clinical phenotype in MPS6 patients."Am. J. Hum. Genet. 58:1127-1134(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Two novel mutations of the arylsulfatase B gene in two Italian patients with severe form of mucopolysaccharidosis."Hum. Mutat. 11:410-410(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome." Science 280:1077-1082(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Maroteaux-Lamy syndrome: five novel mutations and their structural localization."Biochim. Biophys. Acta 1453:185-192(1999) [PubMed] [Europe PMC] [Abstract]
  23. "A novel mutation (Q239R) identified in a Taiwan Chinese patient with type VI mucopolysaccharidosis (Maroteaux-Lamy syndrome)."Hum. Mutat. 15:389-390(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Mucopolysaccharidosis type VI: report of two Taiwanese patients and identification of one novel mutation."J. Formos. Med. Assoc. 100:820-823(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Mutational analysis of mucopolysaccharidosis type VI patients undergoing a trial of enzyme replacement therapy."Hum. Mutat. 23:229-233(2004) [PubMed] [Europe PMC] [Abstract]