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Histidine Decarboxylase (HDC)

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Histidine Decarboxylase (HDC)
CCC G476
HGNC 4855
MGI 96062
PubMed 21873469
RGD 2790
UniProt P19113
Wiki HDC
The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC). This homodimeric enzyme is a pyridoxal phosphate (PLP)-dependent decarboxylase and is highly specific for its histidine substrate. A high degree of homology was found among the HDCs and the dopa decarboxylases (DDC) of rat, mouse, and human.The gene contains 12 exons spanning approximately 24 kb. Genomic DNA blot analysis suggested that HDC is encoded by a single copy gene. Structural analysis showed that the observed heterogeneity of the HDC mRNA is caused by alternative splicing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG476Hu01 Recombinant Histidine Decarboxylase (HDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG476Hu01 Polyclonal Antibody to Histidine Decarboxylase (HDC) WB,IHC
MAG476Hu21 Monoclonal Antibody to Histidine Decarboxylase (HDC) WB; IHC; ICC; IP.
Assay Kits SEG476Hu ELISA Kit for Histidine Decarboxylase (HDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG476Mu01 Recombinant Histidine Decarboxylase (HDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG476Mu01 Polyclonal Antibody to Histidine Decarboxylase (HDC) WB; IHC; ICC; IP.
Assay Kits SEG476Mu ELISA Kit for Histidine Decarboxylase (HDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG476Ra01 Recombinant Histidine Decarboxylase (HDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG476Ra01 Polyclonal Antibody to Histidine Decarboxylase (HDC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histidine Decarboxylase (HDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidine Decarboxylase (HDC) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of the cDNA encoding L-histidine decarboxylase derived from human basophilic leukemia cell line, KU-812-F."Nucleic Acids Res. 18:5891-5891(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15."DNA Seq. 1:395-400(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells."Eur. J. Biochem. 209:533-539(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the L-histidine decarboxylase gene."J. Biol. Chem. 269:1554-1559(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase."J. Biol. Chem. 287:29175-29183(2012) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]