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Adenosylmethionine Decarboxylase 1 (AMD1)

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SAMDC; AdoMetDC; S-Adenosylmethionine Decarboxylase 1; S-adenosylmethionine decarboxylase proenzyme

Adenosylmethionine Decarboxylase 1 (AMD1)
CCC G471
HGNC 457
MGI 88004
PubMed 23260169
RGD 2104
UniProt P17707
The polyamines spermine, spermidine, and putrescine are low molecular weight aliphatic amines essential for cellular proliferation and tumor promotion.
Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) catalyze the rate-limiting steps in polyamine biosynthesis. A concordant rise in ODC and AdoMetDC activity is seen in various neoplastic conditions including colon cancer and benign colonic polyps. It lacks all the introns present in AMD1 and has numerous mutations in the protein-coding region. By fluorescence in situ hybridization, they mapped AMD1 to 6q21-q22 and the pseudogene, which they referred to as AMD2, to Xq28.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG471Hu01 Recombinant Adenosylmethionine Decarboxylase 1 (AMD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adenosylmethionine Decarboxylase 1 (AMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylmethionine Decarboxylase 1 (AMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylmethionine Decarboxylase 1 (AMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylmethionine Decarboxylase 1 (AMD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosylmethionine Decarboxylase 1 (AMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosylmethionine Decarboxylase 1 (AMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylmethionine Decarboxylase 1 (AMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylmethionine Decarboxylase 1 (AMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylmethionine Decarboxylase 1 (AMD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosylmethionine Decarboxylase 1 (AMD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosylmethionine Decarboxylase 1 (AMD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylmethionine Decarboxylase 1 (AMD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylmethionine Decarboxylase 1 (AMD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylmethionine Decarboxylase 1 (AMD1) ELISA Kit Customized Service Offer
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  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity."J. Biol. Chem. 266:18502-18506(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate."J. Biol. Chem. 274:35059-35066(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase."Biochemistry 38:2462-2470(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The crystal structure of human S-adenosylmethionine decarboxylase at 2.25-A resolution reveals a novel fold."Structure 7:583-595(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase."Biochemistry 40:9484-9494(2001) [PubMed] [Europe PMC] [Abstract]