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Adenosylhomocysteinase Like Protein 1 (AHCYL1)

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XPVKONA; IRBIT; DCAL; Putative adenosylhomocysteinase 2; S-Adenosylhomocysteine Hydrolase-Like 1; Inositol 1,4,5-Trisphosphate Receptor-Binding Protein

Adenosylhomocysteinase Like Protein 1 (AHCYL1)
CCC G467
HGNC 344
MGI 2385184
PubMed 11904675
RGD 1309768
UniProt O43865
Wiki AHCYL1
By differential display and 5-prime RACE, Dekker et al. (2002) cloned AHCYL1, which they designated DCAL, from a cDNA library of a Hodgkin disease-derived cell line that is phenotypically similar to activated peripheral blood dendritic cells (DCs). The deduced 530-amino acid protein contains a hydrophilic domain, followed by a domain similar to the methylation pathway enzyme S-adenosylhomocysteine hydrolase (AHCY), including a conserved NAD(+)-binding motif.
The human and mouse AHCYL1 proteins share 100% identity. Northern blot analysis of the Hodgkin disease cell line detected a transcript of about 4.4 kb. RT-PCR detected modest expression of AHCYL1 in fresh blood DCs, but not in any other peripheral blood mononuclear cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG467Hu01 Recombinant Adenosylhomocysteinase Like Protein 1 (AHCYL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adenosylhomocysteinase Like Protein 1 (AHCYL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylhomocysteinase Like Protein 1 (AHCYL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylhomocysteinase Like Protein 1 (AHCYL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylhomocysteinase Like Protein 1 (AHCYL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosylhomocysteinase Like Protein 1 (AHCYL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosylhomocysteinase Like Protein 1 (AHCYL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylhomocysteinase Like Protein 1 (AHCYL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylhomocysteinase Like Protein 1 (AHCYL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylhomocysteinase Like Protein 1 (AHCYL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosylhomocysteinase Like Protein 1 (AHCYL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosylhomocysteinase Like Protein 1 (AHCYL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosylhomocysteinase Like Protein 1 (AHCYL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosylhomocysteinase Like Protein 1 (AHCYL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosylhomocysteinase Like Protein 1 (AHCYL1) ELISA Kit Customized Service Offer
  1. "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation."Immunogenetics 53:993-1001(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis."Exp. Cell Res. 288:35-50(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of a large population of mRNAs from human testis."Genomics 26:151-158(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling."J. Biol. Chem. 281:22471-22484(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes."Science 345:1512-1515(2014) [PubMed] [Europe PMC] [Abstract]