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Betaine Homocysteine Methyltransferase (BHMT)

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Betaine—homocysteine S-methyltransferase

Betaine Homocysteine Methyltransferase (BHMT)
CCC G464
HGNC 1047
MGI 1339972
PubMed 11073719
RGD 621496
UniProt Q93088
Wiki BHMT
Betaine-homocysteine methyltransferase (BHMT; EC 2.1.1.5) is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. The sequence of the predicted 406-amino acid human BHMT is 94% identical to that of the porcine protein.Maximal expression was observed when rats consumed diets deficient in methionine yet rich in methyl donors, such as choline, betaine, or sulfonium analogs of betaine.BHMT2 was rapidly degraded when translated in vitro in rabbit reticulocyte lysates. BHMT2 was stabilized by cotransfection of COS-1 cells with BHMT, and after cotransfection, BHMT2 coprecipitated with BHMT.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG464Hu01 Recombinant Betaine Homocysteine Methyltransferase (BHMT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG464Hu21 Monoclonal Antibody to Betaine Homocysteine Methyltransferase (BHMT) WB; IHC; ICC; IP.
PAG464Hu01 Polyclonal Antibody to Betaine Homocysteine Methyltransferase (BHMT) WB; IHC; ICC; IP.
Assay Kits SEG464Hu ELISA Kit for Betaine Homocysteine Methyltransferase (BHMT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Betaine Homocysteine Methyltransferase (BHMT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Betaine Homocysteine Methyltransferase (BHMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Betaine Homocysteine Methyltransferase (BHMT) Polyclonal Antibody Customized Service Offer
Assay Kits SEG464Mu ELISA Kit for Betaine Homocysteine Methyltransferase (BHMT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG464Ra01 Recombinant Betaine Homocysteine Methyltransferase (BHMT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Betaine Homocysteine Methyltransferase (BHMT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Betaine Homocysteine Methyltransferase (BHMT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Betaine Homocysteine Methyltransferase (BHMT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Betaine Homocysteine Methyltransferase (BHMT) ELISA Kit Customized Service Offer
  1. "Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase."J. Biol. Chem. 271:22831-22838(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene."J. Biol. Chem. 274:7816-7824(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene."Arch. Biochem. Biophys. 345:171-174(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Human betaine-homocysteine methyltransferase is a zinc metalloenzyme."Arch. Biochem. Biophys. 356:93-98(1998) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Betaine-homocysteine methyltransferase: zinc in a distorted barrel."Structure 10:1159-1171(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease."Atherosclerosis 167:205-214(2003) [PubMed] [Europe PMC] [Abstract]