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Absent In Melanoma 1 (AIM1)

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ST4; CRYBG1; Suppression Of Tumorigenicity 4; Beta-Gamma Crystallin Domain Containing 1

Absent In Melanoma 1 (AIM1)
CCC G301
HGNC 356
MGI 109544
PubMed 11700328
UniProt Q9Y4K1
Wiki AIM1
AIM1 (absent in melanoma-1) is a novel gene whose expression is altered in association with tumor suppression in a model of human melanoma . Chromosome banding analysis of human malignant melanoma documented nonrandom alteration in chromosome 6.
All known members of this superfamily contain 2 or 4 characteristic motifs arranged in 1 or 2 symmetrical domains. AIM1, in contrast, contains 12 beta-gamma motifs, suggesting a 6-domain structure resembling a trimer of beta- or gamma-crystallin subunits. The structure of the AIM1 gene shows remarkable similarity to the beta-crystallin genes, with homologous introns delineating equivalent protein structural units.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG301Hu01 Recombinant Absent In Melanoma 1 (AIM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG301Hu21 Monoclonal Antibody to Absent In Melanoma 1 (AIM1) WB; IHC; ICC; IP.
PAG301Hu01 Polyclonal Antibody to Absent In Melanoma 1 (AIM1) WB
Assay Kits SEG301Hu ELISA Kit for Absent In Melanoma 1 (AIM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Absent In Melanoma 1 (AIM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Absent In Melanoma 1 (AIM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Absent In Melanoma 1 (AIM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Absent In Melanoma 1 (AIM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Absent In Melanoma 1 (AIM1) ELISA Kit Customized Service Offer
  1. "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma."Proc. Natl. Acad. Sci. U.S.A. 94:3229-3234(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the fifth crystallin domain of the non-lens protein, absent in melanoma 1."Submitted (JUN-2006) to the PDB data bank
  10. "Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1)."J. Mol. Biol. 381:509-518(2008) [PubMed] [Europe PMC] [Abstract]