Proteasome Subunit Beta Type 4 (PSMb4)

[Edit]

HN3; HsN3; PROS26; 26 kDa prosomal protein; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain

Proteasome Subunit Beta Type 4 (PSMb4)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
PSMB4 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.PSMB4 is mapped to 1q21 by fluorescence in situ hybridization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG264Hu01 Recombinant Proteasome Subunit Beta Type 4 (PSMb4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Beta Type 4 (PSMb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Beta Type 4 (PSMb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Beta Type 4 (PSMb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Beta Type 4 (PSMb4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG264Mu01 Recombinant Proteasome Subunit Beta Type 4 (PSMb4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Beta Type 4 (PSMb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Beta Type 4 (PSMb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Beta Type 4 (PSMb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Beta Type 4 (PSMb4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proteasome Subunit Beta Type 4 (PSMb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proteasome Subunit Beta Type 4 (PSMb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proteasome Subunit Beta Type 4 (PSMb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proteasome Subunit Beta Type 4 (PSMb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proteasome Subunit Beta Type 4 (PSMb4) ELISA Kit Customized Service Offer
  1. "Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues."Biochim. Biophys. Acta 1219:361-368(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and expression of a human pro(tea)some beta-subunit cDNA: a homologue of the yeast PRE4-subunit essential for peptidylglutamyl-peptide hydrolase activity."FEBS Lett. 346:151-155(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)."Biochim. Biophys. Acta 1037:178-185(1990) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUN-1992) to UniProtKB
  7. "Human proteasome subunits from 2-dimensional gels identified by partial sequencing."Biochem. Biophys. Res. Commun. 205:1785-1789(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome."Nature 381:328-331(1996) [PubMed] [Europe PMC] [Abstract]
  10. "HsN3 proteasomal subunit as a target for human immunodeficiency virus type 1 Nef protein."Virology 237:33-45(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Proteasomal degradation of Smad1 induced by bone morphogenetic proteins."J. Biol. Chem. 276:46533-46543(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)."BMC Cell Biol. 3:15-15(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits."FEBS Lett. 553:200-204(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome."Biochem. J. 388:593-603(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways."Hum. Pathol. 38:639-644(2007) [PubMed] [Europe PMC] [Abstract]
  18. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]