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Forkhead Box Protein A2 (FOXA2)

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FOX-A2; HNF3B; TCF3B; Hepatocyte Nuclear Factor 3,Beta; Transcription factor 3B

Forkhead Box Protein A2 (FOXA2)
CCC G208
HGNC 5022
MGI 1347476
PubMed 20483781
RGD 2808
UniProt Q9Y261
Wiki FOXA2
FOXA2 encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin.
FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. The genes encode polypeptides of 468, 459, and 354 amino acids, respectively. Both HNF3A and HNF3B are expressed in tissues of endodermal origin, i.e., stomach, intestines, liver, and lung, HNF3G is more extensively expressed, being present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein A2 (FOXA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein A2 (FOXA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein A2 (FOXA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein A2 (FOXA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein A2 (FOXA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG208Mu01 Recombinant Forkhead Box Protein A2 (FOXA2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG208Mu02 Recombinant Forkhead Box Protein A2 (FOXA2) Positive Control; Immunogen; SDS-PAGE; WB.
APG208Mu61 Active Forkhead Box Protein A2 (FOXA2) Cell culture; Activity Assays.
Antibodies PAG208Mu01 Polyclonal Antibody to Forkhead Box Protein A2 (FOXA2) WB; IHC; ICC; IP.
PAG208Mu02 Polyclonal Antibody to Forkhead Box Protein A2 (FOXA2) WB; IHC; ICC; IP.
Assay Kits SEG208Mu ELISA Kit for Forkhead Box Protein A2 (FOXA2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein A2 (FOXA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein A2 (FOXA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein A2 (FOXA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein A2 (FOXA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein A2 (FOXA2) ELISA Kit Customized Service Offer
  1. "Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young."Diabetologia 43:121-124(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis."Hum. Hered. 50:370-381(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization."Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003) [PubMed] [Europe PMC] [Abstract]
  6. "A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism."J. Biol. Chem. 280:16763-16771(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq."Genome Biol. 10:R129.0-R129.0(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2."J. Biol. Chem. 284:19915-19926(2009) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]