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K-Acetyltransferase 2A (KAT2A)

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GCN5L2; GCN5; PCAF-b; hGCN5; GCN5; STAF97; Lysine acetyltransferase 2A; Histone acetyltransferase GCN5; General Control Of Amino-Acid Synthesis 5-Like 2

K-Acetyltransferase 2A (KAT2A)
CCC G188
HGNC 4201
MGI 1343101
PubMed 17178801
RGD 1307242
UniProt Q92830
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner.
Full-length cDNAs, designated TADA2L and GCN5L2, were isolated from testis. The GCN5L2 predicted 427-amino acid protein is 43% identical to the yeast protein. GCN5L2 was shown to function experimentally as an adaptor in a human cell line. Yang et al. (1996) also cloned GCN5L2; their clone had an additional 49 N-terminal amino acids. Yang et al. (1996) reported that GCN5L2 has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG188Hu01 Recombinant K-Acetyltransferase 2A (KAT2A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 2A (KAT2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 2A (KAT2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 2A (KAT2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 2A (KAT2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant K-Acetyltransferase 2A (KAT2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 2A (KAT2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 2A (KAT2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 2A (KAT2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 2A (KAT2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant K-Acetyltransferase 2A (KAT2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to K-Acetyltransferase 2A (KAT2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to K-Acetyltransferase 2A (KAT2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for K-Acetyltransferase 2A (KAT2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for K-Acetyltransferase 2A (KAT2A) ELISA Kit Customized Service Offer
  1. "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5."Mol. Cell. Biol. 16:593-602(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members."Nucleic Acids Res. 26:2948-2954(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A."Nature 382:319-324(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo."Mol. Cell. Biol. 21:6782-6795(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction."J. Biol. Chem. 274:18285-18289(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc."Mol. Cell. Biol. 20:556-562(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat."J. Biol. Chem. 276:28179-28184(2001) [PubMed] [Europe PMC] [Abstract]
  9. "The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger."Mol. Cell. Biol. 21:5109-5121(2001) [PubMed] [Europe PMC] [Abstract]
  10. "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases."Oncogene 23:2559-2563(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5."Proc. Natl. Acad. Sci. U.S.A. 104:2703-2708(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing."Mol. Cell 29:92-101(2008) [PubMed] [Europe PMC] [Abstract]
  14. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain."J. Mol. Biol. 304:355-370(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A."Proteins 68:403-407(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]