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Dedicator Of Cytokinesis 10 (DOCK10)

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DRIP2; ZIZ3; Zizimin3

Dedicator Of Cytokinesis 10 (DOCK10)
CCC G180
HGNC 23479
MGI 2146320
PubMed 12432077
UniProt Q96BY6
Wiki Dock10
Dock10 shares the same domain arrangement as other members of the DOCK-D/Zizimin subfamily as well as a high level of sequence similarity. It contains a DHR2 domain which is involved in G protein binding and a DHR1 domain which, in some DOCK family proteins, interacts with membrane phospholipids. Like other DOCK-D subfamily proteins Dock10 contains an N-terminal PH domain which, in Dock9/Zizimin1, mediates recruitment to the plasma membrane. The DHR2 domain of Dock10 appears to bind to the small G proteins Cdc42, TC10 and TCL although these interactions are of low affinity. The physiological role of Dock10 is poorly characterised, however a study in lymphocytes has shown that Dock10 expression is upregulated in B-lymphocytes and Chronic Lymphocytic Leukemia (CLL) cells in response to the cytokine IL-4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG180Hu01 Recombinant Dedicator Of Cytokinesis 10 (DOCK10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG180Hu01 Polyclonal Antibody to Dedicator Of Cytokinesis 10 (DOCK10) WB; IHC; ICC; IP.
Assay Kits SEG180Hu ELISA Kit for Dedicator Of Cytokinesis 10 (DOCK10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG180Mu01 Recombinant Dedicator Of Cytokinesis 10 (DOCK10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 10 (DOCK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 10 (DOCK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 10 (DOCK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 10 (DOCK10) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes."Hum. Immunol. 72:531-537(2011) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]