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Dedicator Of Cytokinesis 7 (DOCK7)

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Dedicator Of Cytokinesis 7 (DOCK7)
CCC G177
HGNC 19190
MGI 1914549
PubMed 22842144
UniProt Q96N67
Wiki Dock7
Dock7 is part of a large class of proteins (GEFs) which contibrute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to Guanosine diphosphate (GDP) and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by promoting this nucleotide exchange.
Dock7 and other DOCK family proteins differ from other GEFs in that they do not possess the canonical structure of tandem DH-PH domains known to elicit nucleotide exchange. Instead they possess a DHR2 domain which mediates G protein activation by stabilising it in its nucleotide free state. They also contain a DHR1 domain which, in many DOCK family members, interacts with phospholipids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG177Hu01 Recombinant Dedicator Of Cytokinesis 7 (DOCK7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 7 (DOCK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 7 (DOCK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 7 (DOCK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 7 (DOCK7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dedicator Of Cytokinesis 7 (DOCK7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 7 (DOCK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 7 (DOCK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 7 (DOCK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 7 (DOCK7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG177Ra01 Recombinant Dedicator Of Cytokinesis 7 (DOCK7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dedicator Of Cytokinesis 7 (DOCK7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dedicator Of Cytokinesis 7 (DOCK7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dedicator Of Cytokinesis 7 (DOCK7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dedicator Of Cytokinesis 7 (DOCK7) ELISA Kit Customized Service Offer
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  6. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation and binding partner analysis of the TSC1-TSC2 complex."Biochem. Biophys. Res. Commun. 333:818-826(2005) [PubMed] [Europe PMC] [Abstract]
  8. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness."Am. J. Hum. Genet. 94:891-897(2014) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]