Small Ubiquitin Related Modifier Protein 1 (SUMO1)

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GMP1; OFC10; PIC1; SMT3; SMT3C; SMT3H3; SUMO-1; UBL1; GAP-modifying protein 1; Ubiquitin-homology domain protein PIC1

Small Ubiquitin Related Modifier Protein 1 (SUMO1)
Small ubiquitin-related modifier 1 is a member of the SUMO protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.Sequence analysis of the corresponding gene, termed UBL1, revealed that the gene encodes a 101-amino acid polypeptide with homology to ubiquitin and other ubiquitin-like proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG154Hu01 Recombinant Small Ubiquitin Related Modifier Protein 1 (SUMO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG154Hu21 Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 1 (SUMO1) WB; IHC; ICC; IP.
PAG154Hu01 Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 1 (SUMO1) WB; IHC; ICC; IP.
Assay Kits SEG154Hu ELISA Kit for Small Ubiquitin Related Modifier Protein 1 (SUMO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG154Mu01 Recombinant Small Ubiquitin Related Modifier Protein 1 (SUMO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG154Mu01 Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 1 (SUMO1) WB; IHC; ICC; IP.
Assay Kits SEG154Mu ELISA Kit for Small Ubiquitin Related Modifier Protein 1 (SUMO1) Enzyme-linked immunosorbent assay for Antigen Detection.
HEG154Mu High Sensitive ELISA Kit for Small Ubiquitin Related Modifier Protein 1 (SUMO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Ubiquitin Related Modifier Protein 1 (SUMO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 1 (SUMO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 1 (SUMO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 1 (SUMO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 1 (SUMO1) ELISA Kit Customized Service Offer
  1. "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family."Genomics 40:362-367(1997) [PubMed] [Europe PMC] [Abstract]
  2. "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia."Oncogene 13:971-982(1996) [PubMed] [Europe PMC] [Abstract]
  3. "UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins."Genomics 36:271-279(1996) [PubMed] [Europe PMC] [Abstract]
  4. "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2."Cell 88:97-107(1997) [PubMed] [Europe PMC] [Abstract]
  5. "A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex."J. Cell Biol. 135:1457-1470(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin."J. Immunol. 157:4277-4281(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Preferential modification of nuclear proteins by a novel ubiquitin-like molecule."J. Biol. Chem. 272:14001-14004(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Cell cycle regulation of PML modification and ND10 composition."J. Cell Sci. 112:4581-4588(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif."J. Biol. Chem. 275:36316-36323(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins."Gene 296:65-73(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation."Biochemistry 42:9959-9969(2003) [PubMed] [Europe PMC] [Abstract]
  15. "The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML."Exp. Cell Res. 283:36-50(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1."Biochem. J. 386:325-330(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection."Nat. Struct. Mol. Biol. 12:67-74(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Functional modulation of parkin through physical interaction with SUMO-1."J. Neurosci. Res. 84:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
  20. "SUMO1 haploinsufficiency leads to cleft lip and palate."Science 313:1751-1751(2006) [PubMed] [Europe PMC] [Abstract]
  21. "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia."Cell 131:309-323(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution."J. Proteome Res. 7:4050-4057(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25."Mol. Cell 30:610-619(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  25. "RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation."Nat. Cell Biol. 10:538-546(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  27. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
  31. "SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability."PLoS ONE 6:E23046-E23046(2011) [PubMed] [Europe PMC] [Abstract]
  32. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  33. "The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA."Cancer Res. 72:2275-2284(2012) [PubMed] [Europe PMC] [Abstract]
  34. "PolySUMO-binding proteins identified through a string search."J. Biol. Chem. 287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
  35. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  36. "Structure determination of the small ubiquitin-related modifier SUMO-1."J. Mol. Biol. 280:275-286(1998) [PubMed] [Europe PMC] [Abstract]
  37. "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex."Structure 12:1519-1531(2004) [PubMed] [Europe PMC] [Abstract]
  38. "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1."EMBO J. 24:439-451(2005) [PubMed] [Europe PMC] [Abstract]
  39. "Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation."J. Biol. Chem. 280:40122-40129(2005) [PubMed] [Europe PMC] [Abstract]
  40. "Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex."Nature 435:687-692(2005) [PubMed] [Europe PMC] [Abstract]
  41. "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1."Nature 435:979-982(2005) [PubMed] [Europe PMC] [Abstract]
  42. "SUMO modification of the ubiquitin-conjugating enzyme E2-25K."Nat. Struct. Mol. Biol. 12:264-269(2005) [PubMed] [Europe PMC] [Abstract]
  43. "Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease."Biochem. J. 398:345-352(2006) [PubMed] [Europe PMC] [Abstract]
  44. "SUMO protease SENP1 induces isomerization of the scissile peptide bond."Nat. Struct. Mol. Biol. 13:1069-1077(2006) [PubMed] [Europe PMC] [Abstract]