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Small Ubiquitin Related Modifier Protein 3 (SUMO3)

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SMT3A; SMT3H1; Ubiquitin-like protein SMT3A

Small Ubiquitin Related Modifier Protein 3 (SUMO3)
CCC G153
HGNC 11124
MGI 1336201
PubMed 9119407
RGD 1561022
UniProt P55854
Wiki SUMO3
SUMO proteins, such as SUMO3, and ubiquitin posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability.
The predicted protein of 103 amino acids was found to be a homolog of the S. cerevisiae SMT3 protein, whose gene was previously isolated as a suppressor of mutations in the MIF2 gene. The most prominent difference between SUMO proteins and ubiquitin is the presence of highly variable N-terminal extensions in the SUMO proteins.Expression of SUMO3 was much lower than that of SUMO2, particularly in HeLa and kidney cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG153Hu01 Recombinant Small Ubiquitin Related Modifier Protein 3 (SUMO3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Ubiquitin Related Modifier Protein 3 (SUMO3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Ubiquitin Related Modifier Protein 3 (SUMO3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) ELISA Kit Customized Service Offer

Organism species: S. cerevisiae (Yeast)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG153Ye01 Recombinant Small Ubiquitin Related Modifier Protein 3 (SUMO3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 3 (SUMO3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Ubiquitin Related Modifier Protein 3 (SUMO3) ELISA Kit Customized Service Offer
  1. "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family."Genomics 40:362-367(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3."J. Biol. Chem. 275:6252-6258(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9."J. Biol. Chem. 276:35368-35374(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular features of human ubiquitin-like SUMO genes and their encoded proteins."Gene 296:65-73(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation."Biochemistry 42:9959-9969(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex."Structure 12:1519-1531(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1."Biochem. J. 386:325-330(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3."J. Biol. Chem. 281:15869-15877(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25."Mol. Cell 30:610-619(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."J. Biol. Chem. 286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]
  15. "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage."Genes Dev. 27:2227-2232(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of human SUMO-3 C47S and its binding surface for Ubc9."Biochemistry 44:2790-2799(2005) [PubMed] [Europe PMC] [Abstract]
  17. "The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing."Biochem. J. 397:279-288(2006) [PubMed] [Europe PMC] [Abstract]