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Adaptor Associated Protein Kinase 1 (AAK1)

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AP2-Associated Protein Kinase 1

Adaptor Associated Protein Kinase 1 (AAK1)
CCC G096
HGNC 19679
MGI 1098687
PubMed 21802010
RGD 1305520
UniProt Q2M2I8
Wiki AAK1
Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme encoded by the AAK1 gene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG096Hu01 Recombinant Adaptor Associated Protein Kinase 1 (AAK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adaptor Associated Protein Kinase 1 (AAK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Associated Protein Kinase 1 (AAK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Associated Protein Kinase 1 (AAK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Associated Protein Kinase 1 (AAK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG096Mu01 Recombinant Adaptor Associated Protein Kinase 1 (AAK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adaptor Associated Protein Kinase 1 (AAK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Associated Protein Kinase 1 (AAK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Associated Protein Kinase 1 (AAK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Associated Protein Kinase 1 (AAK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Associated Protein Kinase 1 (AAK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Associated Protein Kinase 1 (AAK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Associated Protein Kinase 1 (AAK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Associated Protein Kinase 1 (AAK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Associated Protein Kinase 1 (AAK1) ELISA Kit Customized Service Offer
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  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Differential requirements for AP-2 in clathrin-mediated endocytosis."J. Cell Biol. 162:773-779(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis."Traffic 9:1791-1800(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway."J. Biol. Chem. 286:18720-18730(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]