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Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4)

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GPR48; G Protein-Coupled Receptor 48

Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4)
CCC G046
HGNC 13299
MGI 1891468
PubMed 23712846
RGD 628615
UniProt Q9BXB1
Wiki LGR4
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain.
The predicted 951-amino acid rat Lgr4 protein contains a signal peptide; N- and C-flanking cysteine-rich sequences separated by 17 LRRs; 5 potential N-glycosylation sites; a transmembrane region; and a 145-residue cytoplasmic tail with multiple phosphorylation sites and a conserved potential protein kinase A phosphorylation site. Northern blot analysis of human tissues detected a 5.5-kb LGR4 transcript in multiple steroidogenic tissues and in a number of other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG046Mu01 Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG046Mu01 Polyclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) WB; IHC; ICC; IP.
Assay Kits SEG046Mu ELISA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leucine Rich Repeat Containing G Protein Coupled Receptor 4 (LGR4) ELISA Kit Customized Service Offer
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  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."Nature 476:293-297(2011) [PubMed] [Europe PMC] [Abstract]
  6. "R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling."Proc. Natl. Acad. Sci. U.S.A. 108:11452-11457(2011) [PubMed] [Europe PMC] [Abstract]
  7. "R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5." PLoS ONE 7:E40976-E40976(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Multi-functional norrin is a ligand for the LGR4 receptor."J. Cell Sci. 126:2060-2068(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits." Nature 497:517-520(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for R-spondin recognition by LGR4/5/6 receptors."Genes Dev. 27:1339-1344(2013) [PubMed] [Europe PMC] [Abstract]