≡

Adenosine Monophosphate Deaminase 2 (AMPD2)

[Edit]

AMPD Isoform L

Adenosine Monophosphate Deaminase 2 (AMPD2)
CCC G009
HGNC 469
MGI 88016
PubMed 23911318
RGD 2110
UniProt Q01433
Wiki AMPD2
Adenosine monophosphate deaminase-2 (EC 3.5.4.6) catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
The deduced 760-amino acid polypeptide has a predicted molecular mass of 88.1 kD and shares significant homology in the C-terminal region with AMPD1. AMPD2 encodes isoform L (liver).AMPD2 is the predominant gene expressed in nonmuscle tissues and smooth muscle of the adult rat and is also the predominant gene expressed in embryonic muscle and undifferentiated myoblasts. Both genes are expressed in cardiac muscle of the adult rat. The peptides encoded by these 2 genes have distinct immunologic properties. Human isoform L corresponds to rat isoform B (liver and kidney).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG009Hu01 Recombinant Adenosine Monophosphate Deaminase 2 (AMPD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG009Hu01 Polyclonal Antibody to Adenosine Monophosphate Deaminase 2 (AMPD2) WB; IHC; ICC; IP.
Assay Kits SEG009Hu ELISA Kit for Adenosine Monophosphate Deaminase 2 (AMPD2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG009Mu01 Recombinant Adenosine Monophosphate Deaminase 2 (AMPD2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adenosine Monophosphate Deaminase 2 (AMPD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosine Monophosphate Deaminase 2 (AMPD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosine Monophosphate Deaminase 2 (AMPD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine Monophosphate Deaminase 2 (AMPD2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosine Monophosphate Deaminase 2 (AMPD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosine Monophosphate Deaminase 2 (AMPD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosine Monophosphate Deaminase 2 (AMPD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosine Monophosphate Deaminase 2 (AMPD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine Monophosphate Deaminase 2 (AMPD2) ELISA Kit Customized Service Offer
  1. "Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA."J. Biol. Chem. 267:22407-22413(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L."Biochem. J. 312:401-410(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters."Biochim. Biophys. Acta 1308:122-132(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder." Cell 154:505-517(2013) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders." Science 343:506-511(2014) [PubMed] [Europe PMC] [Abstract]