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Adenosine A2a Receptor (ADORA2a)

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ADORA2; RDC8; hA2AR

Adenosine A2a Receptor (ADORA2a)
CCC G006
HGNC 263
MGI 99402
PubMed 17329997
RGD 2049
UniProt P29274
Wiki ADORA2a
ADORA2a is a member of the G protein-coupled receptor (GPCR) family which possess seven transmembrane alpha helices. The crystallographic structure of the adenosine A2A receptor PDB 3EML (see figure to the right) reveals a ligand binding pocket distinct from that of other structurally determined GPCRs.
Adenosine A2a Receptoris one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein-coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.As with the A1, the A2A receptors are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG006Hu01 Recombinant Adenosine A2a Receptor (ADORA2a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG006Hu21 Monoclonal Antibody to Adenosine A2a Receptor (ADORA2a) WB; IHC; ICC; IP.
PAG006Hu01 Polyclonal Antibody to Adenosine A2a Receptor (ADORA2a) WB; IHC; ICC; IP.
Assay Kits SEG006Hu ELISA Kit for Adenosine A2a Receptor (ADORA2a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosine A2a Receptor (ADORA2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosine A2a Receptor (ADORA2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosine A2a Receptor (ADORA2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosine A2a Receptor (ADORA2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine A2a Receptor (ADORA2a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenosine A2a Receptor (ADORA2a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenosine A2a Receptor (ADORA2a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenosine A2a Receptor (ADORA2a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenosine A2a Receptor (ADORA2a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenosine A2a Receptor (ADORA2a) ELISA Kit Customized Service Offer
  1. "Molecular characterization of a human brain adenosine A2 receptor."Brain Res. Mol. Brain Res. 15:62-66(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A."Biochem. Biophys. Res. Commun. 223:461-467(1996) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The dopamine D(4) receptor, the ultimate disordered protein."J. Recept. Signal Transduct. 30:331-336(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor."J. Biol. Chem. 270:13987-13997(1995) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor."Mol. Pharmacol. 69:1083-1094(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist."Science 322:1211-1217(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  11. ErratumNat. Genet. 23:373-373(1999)