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Reticulon 4 Receptor (RTN4R)

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NGR; NOGOR; Nogo-66 Receptor

Reticulon 4 Receptor (RTN4R)
CCC F991
HGNC 18601
MGI 2136886
PubMed 18043741
RGD 620810
UniProt Q9BZR6
Wiki RTN4R
Reticulon 4 receptor is the receptor for reticulon 4, oligodendrocytemyelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. The Nogo-66 Receptor (NgR) is a high affinity binding receptor for a region of Nogo, a myelin associated protein that inhibits axon outgrowth. NgR was identified by Strittmatter and colleagues using an expression cloning strategy.NgR is implicated in neuronal plasticity and regeneration. Its relative importance in mediating myelin inhibition in vitro and in vivo is currently under intense investigation, since this protein might be a good drug target for treatment of various neurological conditions such as spinal cord injury and stroke.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 4 Receptor (RTN4R) Recombinant Protein Customized Service Offer
Antibodies PAF991Hu01 Polyclonal Antibody to Reticulon 4 Receptor (RTN4R) WB; IHC; ICC; IP.
Assay Kits SEF991Hu ELISA Kit for Reticulon 4 Receptor (RTN4R) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 4 Receptor (RTN4R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 4 Receptor (RTN4R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 4 Receptor (RTN4R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 4 Receptor (RTN4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 4 Receptor (RTN4R) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 4 Receptor (RTN4R) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 4 Receptor (RTN4R) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 4 Receptor (RTN4R) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 4 Receptor (RTN4R) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 4 Receptor (RTN4R) ELISA Kit Customized Service Offer
  1. "Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration."Nature 409:341-346(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Nogo-66 receptor antagonist peptide promotes axonal regeneration."Nature 417:547-551(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth."Nature 417:941-944(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor."Science 297:1190-1193(2002) [PubMed] [Europe PMC] [Abstract]
  11. "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex."Nat. Neurosci. 7:221-228(2004) [PubMed] [Europe PMC] [Abstract]
  12. "It takes more than two to Nogo."Science 297:1132-1134(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration."J. Neurosci. Res. 67:559-565(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1."Cell. Mol. Neurobiol. 31:27-35(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins."EMBO J. 22:3291-3302(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition."Neuron 38:177-185(2003) [PubMed] [Europe PMC] [Abstract]