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S-Phase Kinase Associated Protein 1 (SKP1)

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SKP1A; EMC19; OCP-II; OCP2; TCEB1L; p19A; Cyclin-A/CDK2-associated p19; RNA polymerase II elongation factor-like protein; Transcription elongation factor B polypeptide 1-like

S-Phase Kinase Associated Protein 1 (SKP1)
CCC F883
HGNC 10899
MGI 103575
PubMed 12820959
RGD 1359648
UniProt P63208
Wiki SKP1A
S-phase kinase-associated protein 1 is a member of the SCF ubiquitin ligase protein complex. It binds to proteins containing an F-box motif, such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis.
The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF883Hu01 Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF883Hu21 Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB; IHC; ICC; IP.
PAF883Hu01 Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) WB,IHC
Assay Kits SEF883Hu ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant S-Phase Kinase Associated Protein 1 (SKP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to S-Phase Kinase Associated Protein 1 (SKP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for S-Phase Kinase Associated Protein 1 (SKP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for S-Phase Kinase Associated Protein 1 (SKP1) ELISA Kit Customized Service Offer
  1. "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase."Cell 82:915-925(1995) [PubMed] [Europe PMC] [Abstract]
  2. "A novel cDNA with homology to an RNA polymerase II elongation factors maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l)."Genomics 29:145-151(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. , Submitted (FEB-1994) to UniProtKB
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma."Proc. Natl. Acad. Sci. U.S.A. 110:3943-3948(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter."Gene 184:163-167(1997) [PubMed] [Europe PMC] [Abstract]
  10. "CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex."Proc. Natl. Acad. Sci. U.S.A. 99:16601-16606(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."Mol. Cell 7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein."Mol. Cell. Biol. 26:5994-6004(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
  14. "SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation."Nature 466:138-142(2010) [PubMed] [Europe PMC] [Abstract]
  15. "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas."Nature 481:90-93(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex."Nature 408:381-386(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex."Nature 416:703-709(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase."Mol. Cell 11:1445-1456(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase."Mol. Cell 20:9-19(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases."Mol. Cell 26:131-143(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase."Proc. Natl. Acad. Sci. U.S.A. 104:5777-5781(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase."J. Biol. Chem. 285:13896-13906(2010) [PubMed] [Europe PMC] [Abstract]