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By database mining, Peeters et al. (2003) identified a gene family related to p53-activated gene-26 (PA26), which they termed the sestrin family. Sequence alignment of human and mouse sestrin protein family members showed that the gene family is highly conserved. The SEST3 gene encodes a deduced 492-amino acid protein.
Using FISH, Peeters et al. (2003) confirmed the localization of the human sestrin genes PA26, SEST2 , and SEST3 to chromosomes 6q21, 1p35.3, and 11q21, respectively. Using the same method, they mapped the mouse Pa26, Sest2, and Sest3 genes to syntenic regions on chromosomes 4, 9, and 10, respectively.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Sestrin 3 (SESN3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Sestrin 3 (SESN3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Sestrin 3 (SESN3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEF876Hu | ELISA Kit for Sestrin 3 (SESN3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF876Mu01 | Recombinant Sestrin 3 (SESN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPF876Mu02 | Recombinant Sestrin 3 (SESN3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAF876Mu01 | Polyclonal Antibody to Sestrin 3 (SESN3) | WB; IHC; ICC; IP. |
| PAF876Mu02 | Polyclonal Antibody to Sestrin 3 (SESN3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEF876Mu | ELISA Kit for Sestrin 3 (SESN3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Sestrin 3 (SESN3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Sestrin 3 (SESN3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Sestrin 3 (SESN3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Sestrin 3 (SESN3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Sestrin 3 (SESN3) | ELISA Kit Customized Service Offer |
- "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse."Hum. Genet. 112:573-580(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]