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Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4)

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TRPM4B; Melastatin-4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4

Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4)
CCC F834
HGNC 17993
MGI 1915917
PubMed 19169264
RGD 620244
UniProt Q8TD43
Wiki TRPM4
TRPM4 has 1,040 amino acids and contains 6 putative transmembrane domains. Northern blot analysis detected TRPM4 expression in most adult tissues tested, with highest levels in heart, prostate, and colon.
In fetus, TRPM4 expression was most abundant in kidney. There were at least 2 distinct bands detected (6.2 and 4.2 kb), indicating alternative splicing of TRPM4. In addition, a smaller but relatively abundant 2.4-kb transcript was detected in testis.The shorter protein results from alternative splicing, with the third and fourth exons being spliced out and the beginning of the first exon being truncated. As a consequence, the first in-frame methionine lies in the fifth exon, resulting in the deletion of the first 174 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF834Mu01 Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF834Mu02 Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF834Mu01 Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) WB; IHC; ICC; IP.
PAF834Mu02 Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) WB; IHC; ICC; IP.
Assay Kits SEF834Mu ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF834Ra01 Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF834Ra01 Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) WB; IHC; ICC; IP.
MAF834Ra21 Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) WB
MAF834Ra23 Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) WB; IHC; ICC; IP.
MAF834Ra22 Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) WB; IHC; ICC; IP.
Assay Kits SEF834Ra ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform."Proc. Natl. Acad. Sci. U.S.A. 98:10692-10697(2001) [PubMed] [Europe PMC] [Abstract]
  2. "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization."Cell 109:397-407(2002) [PubMed] [Europe PMC] [Abstract]
  3. "TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel."Curr. Biol. 13:1153-1158(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Voltage dependence of the Ca2+-activated cation channel TRPM4."J. Biol. Chem. 278:30813-30820(2003) [PubMed] [Europe PMC] [Abstract]
  5. ErratumJ. Biol. Chem. 278:42728-42728(2003)
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries."Circ. Res. 95:922-929(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes."J. Physiol. (Lond.) 558:75-83(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Decavanadate modulates gating of TRPM4 cation channels."J. Physiol. (Lond.) 560:753-765(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b."Pflugers Arch. 448:70-75(2004) [PubMed] [Europe PMC] [Abstract]
  12. "TRPM4 regulates calcium oscillations after T cell activation."Science 306:1374-1377(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4."J. Biol. Chem. 280:6423-6433(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The selectivity filter of the cation channel TRPM4."J. Biol. Chem. 280:22899-22906(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization."J. Biol. Chem. 280:39185-39192(2005) [PubMed] [Europe PMC] [Abstract]
  16. "TRPM4 controls insulin secretion in pancreatic beta-cells."Cell Calcium 41:51-61(2007) [PubMed] [Europe PMC] [Abstract]
  17. "The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate."EMBO J. 25:467-478(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Tissue distribution profiles of the human TRPM cation channel family."J. Recept. Signal Transduct. 26:159-178(2006) [PubMed] [Europe PMC] [Abstract]
  19. "A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity."Mol. Pharmacol. 69:1413-1420(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4)."Biochem. Biophys. Res. Commun. 391:806-811(2010) [PubMed] [Europe PMC] [Abstract]
  21. "TRPM4 enhances cell proliferation through up-regulation of the beta-catenin signaling pathway."J. Cell. Physiol. 226:103-109(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Trpm4 differentially regulates Th1 and th2 function by altering calcium signaling and NFAT localization."J. Immunol. 185:2836-2846(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I."J. Clin. Invest. 119:2737-2744(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease."Circ. Cardiovasc. Genet. 3:374-385(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Mutational spectrum in the Ca(2+) -activated cation channel gene TRPM4 in patients with cardiac conductance disturbances."Hum. Mutat. 33:109-117(2012) [PubMed] [Europe PMC] [Abstract]