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Phosphodiesterase 3A, cGMP Inhibited (PDE3A)

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CGI-PDE; Cyclic GMP-inhibited phosphodiesterase A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Phosphodiesterase 3A, cGMP Inhibited (PDE3A)
CCC F639
HGNC 8778
MGI 1860764
PubMed 12154085
RGD 61942
UniProt Q14432
Wiki PDE3
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents .
ORF encodes a predicted protein of 125 kD. A single mRNA species hybridized with a 4-kb EcoRI restriction fragment of the cDNA containing the entire ORF. The C-terminal region of the deduced amino acid sequence contains a putative catalytic domain conserved among mammalian PDE families.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 3A, cGMP Inhibited (PDE3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 3A, cGMP Inhibited (PDE3A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 3A, cGMP Inhibited (PDE3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 3A, cGMP Inhibited (PDE3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF639Ra01 Recombinant Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF639Ra21 Monoclonal Antibody to Phosphodiesterase 3A, cGMP Inhibited (PDE3A) WB; IHC; ICC; IP.
PAF639Ra01 Polyclonal Antibody to Phosphodiesterase 3A, cGMP Inhibited (PDE3A) WB; IHC; ICC; IP.
Assay Kits SEF639Ra ELISA Kit for Phosphodiesterase 3A, cGMP Inhibited (PDE3A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase."Proc. Natl. Acad. Sci. U.S.A. 89:3721-3725(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis."Blood 88:1321-1329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum."Chem. Biol. Interact. 119:593-598(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase."Biochim. Biophys. Acta 1205:189-198(1994) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]