Piccolo (PCLO)

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ACZ; Aczonin; Presynaptic Cytomatrix Protein

Piccolo (PCLO)
Among the components of the PCM that orchestrate these events are Bassoon (BSN), RIM (RBBP8), Oboe, and Piccolo (PCLO).The 5-prime terminus of the human sequence had yet to be determined, but the authors were able to deduce nearly the entire human PCLO protein. Sequence analysis indicated that the deduced 4,880-amino acid rat Pclo protein is 86% identical to human PCLO. In addition, PCLO shares significant amino acid sequence homology with BSN. BSN and PCLO share 10 homology regions, or PBH regions. PBH1 and PBH2 contain 2 double-zinc finger motifs. PBH4, PBH6, and PBH8 are likely to form coiled-coil structures. At the C terminus, unlike BSN but like RIM and Oboe, PCLO contains a PDZ domain and a C2 domain. The PCLO C2 domain contains all the asp residues required for calcium binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF631Hu01 Recombinant Piccolo (PCLO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Piccolo (PCLO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Piccolo (PCLO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Piccolo (PCLO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Piccolo (PCLO) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF631Mu01 Recombinant Piccolo (PCLO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF631Mu01 Polyclonal Antibody to Piccolo (PCLO) WB; IHC; ICC; IP.
Assay Kits SEF631Mu ELISA Kit for Piccolo (PCLO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF631Ra01 Recombinant Piccolo (PCLO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF631Ra01 Polyclonal Antibody to Piccolo (PCLO) WB; IHC; ICC; IP.
Assay Kits SEF631Ra ELISA Kit for Piccolo (PCLO) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin."J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Solution structure of RSGI RUH-003, a PDZ domain of hypothetical KIAA0559 protein from human."Submitted (JAN-2004) to the PDB data bank