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Mitofusin 2 (MFN2)

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CMT2A; CMT2A2; CPRP1; HSG; MARF; Transmembrane GTPase MFN2

Mitofusin 2 (MFN2)
CCC F591
HGNC 16877
MGI 2442230
PubMed 16714318
RGD 628843
UniProt O95140
Wiki MFN2
Mitofusin-2 is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network.
This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF591Hu01 Recombinant Mitofusin 2 (MFN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF591Hu01 Polyclonal Antibody to Mitofusin 2 (MFN2) WB; IHC; ICC; IP.
Assay Kits SEF591Hu ELISA Kit for Mitofusin 2 (MFN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitofusin 2 (MFN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitofusin 2 (MFN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitofusin 2 (MFN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitofusin 2 (MFN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitofusin 2 (MFN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF591Ra01 Recombinant Mitofusin 2 (MFN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF591Ra01 Polyclonal Antibody to Mitofusin 2 (MFN2) WB; IHC; ICC; IP.
Assay Kits SEF591Ra ELISA Kit for Mitofusin 2 (MFN2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity."J. Biol. Chem. 278:17190-17197(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Dysregulation of HSG triggers vascular proliferative disorders."Nat. Cell Biol. 6:872-883(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Control of mitochondrial morphology by a human mitofusin."J. Cell Sci. 114:867-874(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo."J. Cell Sci. 115:1663-1674(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis."J. Cell Biol. 159:931-938(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells."J. Cell Sci. 116:2763-2774(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A." Nat. Genet. 36:449-451(2004) [PubMed] [Europe PMC] [Abstract]
  13. Erratum Nat. Genet. 36:660-660(2004)
  14. "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2."J. Biol. Chem. 282:5670-5681(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission."J. Biol. Chem. 288:27584-27593(2013) [PubMed] [Europe PMC] [Abstract]
  17. "PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria."Science 340:471-475(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A."Hum. Genet. 116:23-27(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2."Ann. Neurol. 59:276-281(2006) [PubMed] [Europe PMC] [Abstract]
  20. "The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan."PLoS ONE 6:E29393-E29393(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges."J. Neurol. 261:970-982(2014) [PubMed] [Europe PMC] [Abstract]