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Chloride Intracellular Channel Protein 4 (CLIC4)

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H1; CLIC4L; huH1; p64H1; Intracellular chloride ion channel protein p64H1

Chloride Intracellular Channel Protein 4 (CLIC4)
CCC F304
HGNC 13518
MGI 1352754
PubMed 23416981
RGD 61857
UniProt Q9Y696
Wiki CLIC4
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).The 253-amino acid CLIC4 protein is 97%, 67%, and 66% identical to rat H1 and human CLIC1 and CLIC2, respectively. CLIC4 has 5 potential phosphorylation sites. Northern blot analysis revealed ubiquitous expression of a 4.5-kb CLIC4 transcript, with prominent expression in heart, placenta, and skeletal muscle as well as pancreatic carcinoma cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF304Hu01 Recombinant Chloride Intracellular Channel Protein 4 (CLIC4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF304Hu02 Recombinant Chloride Intracellular Channel Protein 4 (CLIC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF304Hu01 Polyclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC; IP.
LAF304Hu71 Biotin-Linked Polyclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC.
MAF304Hu21 Monoclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC; IP.
Assay Kits SEF304Hu ELISA Kit for Chloride Intracellular Channel Protein 4 (CLIC4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF304Mu01 Recombinant Chloride Intracellular Channel Protein 4 (CLIC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF304Mu01 Polyclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC; IP.
LAF304Mu71 Biotin-Linked Polyclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Chloride Intracellular Channel Protein 4 (CLIC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Intracellular Channel Protein 4 (CLIC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF304Ra01 Recombinant Chloride Intracellular Channel Protein 4 (CLIC4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF304Ra02 Recombinant Chloride Intracellular Channel Protein 4 (CLIC4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF304Ra01 Polyclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC; IP.
LAF304Ra71 Biotin-Linked Polyclonal Antibody to Chloride Intracellular Channel Protein 4 (CLIC4) WB; IHC; ICC.
Assay Kits SEF304Ra ELISA Kit for Chloride Intracellular Channel Protein 4 (CLIC4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression."Am. J. Physiol. 276:F398-F408(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons."J. Neurosci. 19:2919-2928(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (FEB-2006) to UniProtKB
  6. "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli."Mol. Biol. Cell 11:1509-1521(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts."Am. J. Pathol. 161:471-480(2002) [PubMed] [Europe PMC] [Abstract]
  8. "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member."J. Biol. Chem. 277:40973-40980(2002) [PubMed] [Europe PMC] [Abstract]
  9. "CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells."Cell Motil. Cytoskeleton 56:159-172(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis."J. Biol. Chem. 280:42397-42404(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers."Clin. Cancer Res. 13:121-131(2007) [PubMed] [Europe PMC] [Abstract]
  12. "CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation."J. Cell Sci. 120:2631-2640(2007) [PubMed] [Europe PMC] [Abstract]
  13. "CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression."Biochem. Biophys. Res. Commun. 369:603-608(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro."Angiogenesis 12:209-220(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4."FEBS J. 272:4996-5007(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals."Biochem. Biophys. Res. Commun. 343:1272-1278(2006) [PubMed] [Europe PMC] [Abstract]