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Carboxylesterase 2 (CES2)

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CE-2; CES2A1; PCE-2; iCE; Intestine,Liver; Methylumbelliferyl-acetate deacetylase 2; Cocaine esterase

Carboxylesterase 2 (CES2)
CCC F282
HGNC 1864
MGI 3648740
PubMed 19185566
UniProt O00748
Wiki CES2
Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters.
The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF282Hu01 Recombinant Carboxylesterase 2 (CES2) Positive Control; Immunogen; SDS-PAGE; WB.
EPF282Hu61 Eukaryotic Carboxylesterase 2 (CES2) Positive Control; Immunogen; SDS-PAGE; WB.
APF282Hu61 Active Carboxylesterase 2 (CES2) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Carboxylesterase 2 (CES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxylesterase 2 (CES2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF282Hu ELISA Kit for Carboxylesterase 2 (CES2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxylesterase 2 (CES2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxylesterase 2 (CES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxylesterase 2 (CES2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxylesterase 2 (CES2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxylesterase 2 (CES2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF282Ra01 Recombinant Carboxylesterase 2 (CES2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Carboxylesterase 2 (CES2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxylesterase 2 (CES2) Polyclonal Antibody Customized Service Offer
Assay Kits SEF282Ra ELISA Kit for Carboxylesterase 2 (CES2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver."Biochem. Biophys. Res. Commun. 233:117-120(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin."J. Biol. Chem. 272:14769-14775(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2)."Drug Metab. Pharmacokinet. 18:327-332(2003) [PubMed] [Europe PMC] [Abstract]