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Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E)

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BII; CACNL1A6; CACH6; Brain calcium channel II; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3

Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E)
CCC F241
HGNC 1392
MGI 106217
PubMed 17189400
RGD 2246
UniProt Q15878
Wiki CACNa1E
CACNa1E encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell.
The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants of the gene described here have been observed but have not been thoroughly characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF241Mu01 Recombinant Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Positive Control; Immunogen; SDS-PAGE; WB.
RPF241Mu02 Recombinant Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF241Mu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) WB; IHC; ICC; IP.
PAF241Mu02 Polyclonal Antibody to Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) WB; IHC; ICC; IP.
Assay Kits SEF241Mu ELISA Kit for Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) ELISA Kit Customized Service Offer
  1. "Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit."Recept. Channels 2:255-270(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and functional characterization of neuronal alpha 1E calcium channel subtypes."J. Biol. Chem. 269:22347-22357(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Mutations in EFHC1 cause juvenile myoclonic epilepsy." Nat. Genet. 36:842-849(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+."Structure 16:607-620(2008) [PubMed] [Europe PMC] [Abstract]