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Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S)

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CACNL1A3; CCHL1A3; Cav1.1; HOKPP; MHS5; hypoPP; DHPR; Dihydropyridine Receptor; Voltage-gated calcium channel subunit alpha Cav1.1

Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S)
CCC F235
HGNC 1397
MGI 88294
PubMed 22901280
UniProt Q13698
Wiki Cav1.1
CACNa1S encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. Cav1.1 is a voltage-dependent calcium channel found in the transverse tubule of muscles. In skeletal muscle it associates with the ryanodine receptor RyR1 of the sarcoplasmic reticulum via a mechanical linkage. It senses the voltage change caused by the end-plate potential from nervous stimulation and propagated by sodium channels as action potentials to the T-tubules. When the muscle depolarises, the channel opens to allow calcium entry, as well as activating RyR1 which mediates much greater calcium entry from the sarcoplasmic reticulum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF235Hu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF235Mu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Positive Control; Immunogen; SDS-PAGE; WB.
RPF235Mu02 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF235Mu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) WB; IHC; ICC; IP.
PAF235Mu02 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) WB; IHC; ICC; IP.
Assay Kits SEF235Mu ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF235Ra01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) ELISA Kit Customized Service Offer
  1. "Cloning of the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3)."Genomics 24:608-609(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The structure of the gene encoding the human skeletal muscle alpha 1 subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3)."Genomics 31:392-394(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Assignment of the human gene for the alpha-1 subunit of the skeletal muscle DHP-sensitive calcium channel (CACNL1A3) to chromosome 1q31-q32."Genomics 15:107-112(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Dihydropyridine receptor mutations cause hypokalemic periodic paralysis."Cell 77:863-868(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Association of novel single nucleotide polymorphisms in the calcium channel alpha 1 subunit gene (Ca(v)1.1) and thyrotoxic periodic paralysis."J. Clin. Endocrinol. Metab. 89:1340-1345(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A calcium channel mutation causing hypokalemic periodic paralysis."Hum. Mol. Genet. 3:1415-1419(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Malignant-hyperthermia susceptibility is associated with a mutation of the alpha-1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle."Am. J. Hum. Genet. 60:1316-1325(1997) [PubMed] [Europe PMC] [Abstract]
  10. "The genotype and clinical phenotype of Korean patients with familial hypokalemic periodic paralysis."J. Korean Med. Sci. 22:946-951(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Hypokalaemic periodic paralysis due to the CACNA1S R1239H mutation in a large African family."Neuromuscul. Disord. 17:419-422(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Voltage sensor charge loss accounts for most cases of hypokalemic periodic paralysis."Neurology 72:1544-1547(2009) [PubMed] [Europe PMC] [Abstract]