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Beta-1,3-Glucuronyltransferase 3 (b3GAT3)

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GLCATI; GlcAT-I; Glucuronosyltransferase I; Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 3; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase

Beta-1,3-Glucuronyltransferase 3 (b3GAT3)
CCC F201
HGNC 923
MGI 1919977
PubMed 21763480
UniProt O94766
Wiki B3GAT3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.
Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF201Hu01 Recombinant Beta-1,3-Glucuronyltransferase 3 (b3GAT3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 3 (b3GAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 3 (b3GAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-Glucuronyltransferase 3 (b3GAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-Glucuronyltransferase 3 (b3GAT3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Beta-1,3-Glucuronyltransferase 3 (b3GAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Beta-1,3-Glucuronyltransferase 3 (b3GAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Beta-1,3-Glucuronyltransferase 3 (b3GAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Beta-1,3-Glucuronyltransferase 3 (b3GAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta-1,3-Glucuronyltransferase 3 (b3GAT3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans."J. Biol. Chem. 273:6615-6618(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues."J. Biol. Chem. 275:28254-28260(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway."Proc. Natl. Acad. Sci. U.S.A. 96:974-979(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans."FEBS Lett. 459:415-420(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Faulty initiation of proteoglycan synthesis causes cardiac and joint defects." Am. J. Hum. Genet. 89:15-27(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans."J. Biol. Chem. 289:6695-6708(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I."J. Biol. Chem. 275:34580-34585(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA."J. Biol. Chem. 277:21869-21873(2002) [PubMed] [Europe PMC] [Abstract]
  13. "2-o-phosphorylation of xylose and 6-O-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis."J. Biol. Chem. 283:16801-16807(2008) [PubMed] [Europe PMC] [Abstract]