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Bromodomain Containing Protein 1 (BRD1)

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BRL; BRPF2; BR140-like protein; Bromodomain and PHD finger-containing protein 2

Bromodomain Containing Protein 1 (BRD1)
CCC F131
HGNC 1102
MGI 1924161
PubMed 21753189
UniProt O95696
The MLL is reciprocally translocated with 1 of a number of different partner genes in human acute leukemias. The precise mechanism of oncogenic transformation is unclear since most of the partner genes encode unrelated proteins. However, 2 partner genes, AF10 and AF17, are related through the presence of a cysteine-rich region and a leucine zipper.
Overall, the protein was most closely related to the BR140 protein , and was therefore designated BRL (BR140-like gene). Northern blot analysis revealed that a 4.6-kb BRL transcript is expressed at high levels in testis and in several cell lines. A monoclonal antibody raised to a BRL peptide sequence confirmed its widespread expression as a 120-kD protein and demonstrated localization to the nucleus of spermatocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF131Hu01 Recombinant Bromodomain Containing Protein 1 (BRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF131Hu01 Polyclonal Antibody to Bromodomain Containing Protein 1 (BRD1) WB; IHC; ICC; IP.
Assay Kits SEF131Hu ELISA Kit for Bromodomain Containing Protein 1 (BRD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bromodomain Containing Protein 1 (BRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bromodomain Containing Protein 1 (BRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bromodomain Containing Protein 1 (BRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bromodomain Containing Protein 1 (BRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bromodomain Containing Protein 1 (BRD1) ELISA Kit Customized Service Offer
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  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes."Mol. Cell. Biol. 28:6828-6843(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF)."J. Biol. Chem. 286:36944-36955(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Structural and histone binding ability characterizations of human PWWP domains."PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Histone recognition and large-scale structural analysis of the human bromodomain family."Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]