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Immunoglobulin Transcription Factor 1 (ITF1)

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TCF3; E2A; VDIR; Transcription Factor 3; E2A Immunoglobulin Enhancer Binding Factors E12/E47; Transcription Factor E2-alpha; VDR Interacting Repressor

Immunoglobulin Transcription Factor 1 (ITF1)
CCC E860
HGNC 11633
MGI 98510
RGD 620914
UniProt P15923
The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression .
Expression of immunoglobulin genes depends on various sequence motifs in their enhancer and promoter regions. One class of such sequences is the E box, which is found in both heavy and light chain enhancers. The kappa-E2 site has been shown to be important for light chain gene transcription. To isolate cDNAs encoding kappa-E2-binding proteins, Murre et al. (1989) screened a cDNA expression library derived from a human B-cell lymphoma cell line (BJAB) with an oligonucleotide containing a trimerized kappa-E2 site. They identified a partial cDNA encoding a protein that they designated E12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin Transcription Factor 1 (ITF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin Transcription Factor 1 (ITF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Transcription Factor 1 (ITF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Transcription Factor 1 (ITF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Transcription Factor 1 (ITF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE860Mu01 Recombinant Immunoglobulin Transcription Factor 1 (ITF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Immunoglobulin Transcription Factor 1 (ITF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Transcription Factor 1 (ITF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Transcription Factor 1 (ITF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Transcription Factor 1 (ITF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin Transcription Factor 1 (ITF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin Transcription Factor 1 (ITF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Transcription Factor 1 (ITF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Transcription Factor 1 (ITF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Transcription Factor 1 (ITF1) ELISA Kit Customized Service Offer
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  2. "Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor."Cell 60:535-545(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins."Cell 56:777-783(1989) [PubMed] [Europe PMC] [Abstract]
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  7. "Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47."DNA Seq. 2:197-202(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif."Science 247:467-470(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains."Proc. Natl. Acad. Sci. U.S.A. 87:4722-4726(1990) [PubMed] [Europe PMC] [Abstract]
  10. "The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias."Blood 77:687-693(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia."Science 257:531-534(1992) [PubMed] [Europe PMC] [Abstract]
  12. "The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors."Gene 201:169-177(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a novel molecular partner of the E2A gene in childhood leukemia."Leukemia 13:369-375(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD."Mol. Endocrinol. 18:776-790(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary."Mol. Hum. Reprod. 10:373-381(2004) [PubMed] [Europe PMC] [Abstract]
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  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins."Protein Eng. 6:41-50(1993) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Nine-amino-acid transactivation domain: establishment and prediction utilities."Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]