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Interleukin 1 Zeta (IL1z)

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IL1F7; IL37; FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H4; IL-1RP1; IL1H4; IL1RP1; Interleukin 37; Interleukin-1-Related Protein; Interleukin 1 Family, Member 7

Interleukin 1 Zeta (IL1z)
CCC E842
HGNC 15563
UniProt Q9NZH6
IL1zis a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE842Hu01 Recombinant Interleukin 1 Zeta (IL1z) Positive Control; Immunogen; SDS-PAGE; WB.
RPE842Hu02 Recombinant Interleukin 1 Zeta (IL1z) Positive Control; Immunogen; SDS-PAGE; WB.
APE842Hu01 Active Interleukin 1 Zeta (IL1z) Cell culture; Activity Assays.
APE842Hu02 Active Interleukin 1 Zeta (IL1z) Cell culture; Activity Assays.
Antibodies PAE842Hu01 Polyclonal Antibody to Interleukin 1 Zeta (IL1z) WB; IHC; ICC; IP.
MAE842Hu22 Monoclonal Antibody to Interleukin 1 Zeta (IL1z) WB; IHC; ICC; IP.
LAE842Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 1 Zeta (IL1z) WB; IHC; ICC.
LAE842Hu81 FITC-Linked Polyclonal Antibody to Interleukin 1 Zeta (IL1z) WB; IHC; ICC; IF.
PAE842Hu02 Polyclonal Antibody to Interleukin 1 Zeta (IL1z) WB; IHC; ICC; IP.
Assay Kits SCE842Hu CLIA Kit for Interleukin 1 Zeta (IL1z) Chemiluminescent immunoassay for Antigen Detection.
SEE842Hu ELISA Kit for Interleukin 1 Zeta (IL1z) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Zeta (IL1z) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Zeta (IL1z) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Zeta (IL1z) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Zeta (IL1z) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Zeta (IL1z) ELISA Kit Customized Service Offer
  1. "Identification and initial characterization of four novel members of the interleukin-1 family."J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp."Cytokine 13:1-7(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Four new members expand the IL-1 superfamily."J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization of the interleukin-1 locus."Genomics 79:726-733(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines."J. Immunol. 180:5477-5482(2008) [PubMed] [Europe PMC] [Abstract]
  9. "IL-37 is a fundamental inhibitor of innate immunity."Nat. Immunol. 11:1014-1022(2010) [PubMed] [Europe PMC] [Abstract]